NIST Standard Reference Materials to Aid Human Identity Testing Applications

The National Institute of Standards and Technology (NIST) ensures exact and compatible measurements through the generation, certification, and issuance of Standard Reference Materials (SRMs). The FBI Quality Assurance Standards for Forensic DNA Testing Laboratories, initially issued by the DNA Advisory Board in October 1998, state that "The laboratory shall check its DNA procedures annually or whenever substantial changes are made to the protocol(s) against an appropriate and available NIST standard reference material or standard traceable to a NIST standards" (Standard 9.5). The primary NIST SRM used for this purpose is SRM 2391c, which contains certified allele calls for the 13 CODIS (Combined DNA Index System) STR loci.

Please contact Becky Steffen (301-975-4275; if you have any questions.

To link to the NIST Standard Reference Materials home page and access to SRM certificates: 


SRM 2391c - PCR-based DNA Profiling Standard (certificate updated April 2015)

SRM 2392-I - Mitochondrial DNA Sequencing (Human HL-60 DNA)

SRM 2372 - Human DNA Quantitation Standard



Last Updated: 09/21/2015