NIST Standard Reference Materials to Aid Human Identity Testing Applications

The National Institute of Standards and Technology (NIST) ensures exact and compatible measurements through the generation, certification, and issuance of Standard Reference Materials (SRMs). The FBI Quality Assurance Standards for Forensic DNA Testing Laboratories, issued by the DNA Advisory Board in October 1998, state that "The laboratory shall check its DNA procedures annually or whenever substantial changes are made to the protocol(s) against an appropriate and available NIST standard reference material or standard traceable to a NIST standards" (Standard 9.5). The primary NIST SRM used for this purpose is SRM 2391b, which contains certified allele calls for the 13 CODIS (Combined DNA Index System) STR loci.

To link to the NIST technology services home page and access to SRM certificates, click on the SRM image.

NIST SRMsFor Online Ordering of NIST SRMs: 

SRM 2391b - PCR-based DNA Profiling Standard

SRM 2392-I - Mitochondrial DNA Sequencing (Human HL-60 DNA)

SRM 2395 - Human Y-Chromosome DNA Profiling Standard; addition information on SRM 2395 is available at

SRM 2372 - Human DNA Quantitation Standard (available as of October 2007)

SRM 2390 - DNA Profiling Standard for RFLP testing

Information on Components Present in SRM 2391b



Last Updated: 06/09/2009