• Combustion Simulation Databases for Real Transportation Fuels
• Advanced Propulsion Systems Demand Accurate Property Data
• Gas Standards in Support of NASA’s Space Shuttle Monitoring Program
• New Nitric Oxide Standards for Next-Generation Low-Emission Vehicles

Biomaterials

• In Vivo 3-D Mapping of Nanoparticle Biomarkers in Cells and Tissues
• Temperature-Controlled Cluster SIMS Depth Profiling in Polymeric Materials
• Protein Stability via Speed of Sound and Density Measurements

Chemicals and Allied Products

• The Transport Properties of Pentafluoroethane (R125)
• IUPAC Partnership Develops Standards and a Data Retrieval System for Ionic Liquids
• The IUPAC International Chemical Identifier (InChI)

Data and Informatics

• ThermoML – a New IUPAC Standard for Thermodynamic Data Communications
• ThermoData Engine: New Generation Expert System for Thermodynamic Data Critical Evaluation
• Systematic Validation and Improvement of Quantum Chemistry Methods for the Prediction of Physical and Chemical Properties
• The NIST Chemistry WebBook
• Spectrum Generation in NISTMonte

Energy and Environmental Technologies

• Marine Environmental Specimen Bank Activities
• Metrology for Marine Gene Expression – Environmental Biosensors
• Standard Reference Materials (SRMs) for Contaminants in Marine Tissue and Sediment
• Characterizing Natural Organic Material from the Occoquan Watershed (Northern Virginia, US) using Fluorescence Spectroscopy and PARAFAC
• Radio-Frequency Resonator as a Primary Hygrometer
• Flow Standards for Natural Gas
• New Low Sulfur in Diesel Fuel SRMs
• Interlaboratory Comparison Exercises for Organic Contaminants and Trace Elements in Marine Sediments and Tissues
• NIST Aids NOAA with Bottlenose Dolphin Health Assessments
• Simultaneous Determination of Sulfur Isotopic Composition and Concentration in Two High-Elevation Snowpits Using a 33S/36S Double Spike Technique
• Cell Cryopreservation – Quantitative Cell Biology
• Establishing Measurement Traceability for Gaseous Mercury Emissions Monitoring
• Improving Measurements with NIST’s Ozone Reference Standard
• Method Development and Measurements of Polybrominated Diphenyl Ethers (PBDEs) in Tissue, Serum, and Sediment SRMs
• Absorption Coefficient Measurements of Carbonaceous-Based Aerosol Particles
• Standards Development and Measurements to Support Global Climate Change Studies
• SRMs for Contaminants on Air Particulate Matter Less Than 2.5 µm (PM2.5)
• SRMs for Organic Contaminants in Human Serum
• New SRM for Organic Contaminants in House Dust

Forensics and Homeland Security

• Decontamination of Bacillus Spores Associated with Drinking Water Systems
• Explosives on Surfaces: A Sticky Problem
• Algorithm to Facilitate Inter-Instrument Comparison of Raman Spectral Libraries
• Evaluation of Oleoresin Capsicum (Pepper Spray) Canisters for Chemical Content and Reliability
• Production of Uniform Test Particle Standards by Ink-Jet Printing
• High-Resolution X-Ray Spectroscopy by Microcalorimetry
• Collection Efficiency of Particle Residues by Contact Swiping
• Methods to Characterize Ricin for the Development of Reference Materials for Testing Detection Devices
• Testing Candidate DNA Quantitation Standards with Real-Time Quantitative PCR methods
• Determination of Traces of Fissionable Materials using Delayed Neutron Activation Analysis
• Developing a NIST Reference Material for Trace Explosives Detection
• On-Demand Ultratrace Vapor Calibration and Testing Device Enabled by Piezoelectric Technology
• The Evaluation of Autosomal SNP Assays
• Microfluidic Devices for Rapid DNA Analysis for Human Identification
• Direct Preparation of Particles from Liquid Suspension for Rapid Identification and Screening
• The Production of Trace Level Explosive Standards Using Drop-on-Demand Ink-Jet Printing Technology

Food and Nutrition

• Development of Primary Methods for Determining the Mass of Nucleic Acids
• Ginkgo biloba Dietary Supplement Standard Reference Materials
• Development of Multivitamin/Multielement Dietary Supplement SRM and SRMs to Assess Nutritional Status
• Development of SRMs for Botanical Dietary Supplements

Health and Medical Technologies

• Bringing a Greater in vivo Relevance to in vitro Measurements
• Telomerase Biomarker Reference Standards for the Detection of Cancer
• Development of a Novel Nanotube Array Biosensor for Real-Time Detection of Volatile Small Molecule Biomarkers Directly Released from Cell Cultures
• NIST Facilitates the Development of Medicines for HIV/AIDS
• Development of a Reference Method for the Quantification of Serum C-Reactive Protein
• Reference Materials for Electron Microscopy of Particulate Drug Delivery Systems
• Metallomics: A Multidisciplinary Approach for the Qualitative and Quantitative Determination of Metalloproteins used as Health and Disease Markers
• A Multistate Model for the Fluorescence Response of R-Phycoerythrin
• Three-Dimensional Molecular Imaging Secondary Ion Mass Spectrometry
• Development of NIST SRM 2394 Heteroplasmic Mitochondrial DNA Mutation Detection Standard
• Mitochondrial DNA as a Biomarker of Disease Detection
• Production of Spike-in Controls for Gene Expression Assay Validation
• Nexplorer: Phylogenetic Exploration of Sequence Family Data
• Polyamines Stimulate the Formation of Mutagenic 1,N2-Propano-Deoxyguanosine Adducts from Acetaldehyde
• Surface Chemistry Optimization for Emerging Health Care Technologies
• Comparison of Fluorescein and Phycoerythrin Conjugates for Quantifying CD20 Expression on Normal and Leukemic B-Cells
• Development of Reference Methods and Materials for the Determination of Hormones in Human Serum
• Development of Reference Methods and Reference Materials for Clinical Diagnostic Markers
• Standards and Technologies for Early Cancer Biomarker Validation
• Stability of Arsenic Species in Urine
• High-Resolution 3D Imaging for Nanoparticle and Cell Systems

Industrial and Analytical Instruments and Services

• Anomalies in Polymer-Based Helium Leak Standards
• High Performance Oxide and Polymer Nanostructures for Advanced Solid-State Chemical Microsensors
• Quantitative Fluorescence Measurements: An International Comparison Study
• Photoacoustic Spectroscopy for Quantitation of Trace Gases in Air
• Measurements of the Bulk Viscosity of Xenon (BVX)
• High-Stability Transfer Standard for the Barometric Pressure Range of 100 Pa to 130 kPa
• Gas Standards Based on Optical Spectroscopies
• Sonic Nozzles as Primary Standards
• Upgrades for Cold Neutron Beam Facilities
• Development of a New Multi-Nutrient Fertilizer Standard Reference Material
• Automatic Mass Spectral Deconvolution and Identification Software (AMDIS)
• Detection of Hazardous Chemicals Using Temperature-Programmed Sensing in Solid-State Gas Microsensor Arrays
• Properties of Standard Platinum Resistance Thermometers
• Atomic Standard of Pressure
• Calculations of Electron Stopping Powers for Electron Energies Between 100 eV and 30 keV
• Progress Toward Realizing Pressure with Dimensionally-Characterized Piston Gauges
• Reference Libraries of Mass Spectra for Health and Environmental Science
• Johnson Noise Thermometry (JNT)
• Investigation of Arsenic Oxidation State Speciation in Primary Calibration Solutions and Effects on ICP-OES Measurements
• Development of the First Natural-Matrix SRM for Solid-Sampling Analytical Instruments

Microelectronics

• Accurate Flow Meter and Viscometer for Gases
• C60+ Cluster Source for Secondary Ion Mass Spectrometry
• Thermophysical Properties of Gases used in Semiconductor Processing
• Non-Contact Free Carrier Density Measurements for Compound Semiconductors
• Atomic Layer Deposition: Process Models and Metrologies
• Horizontal Growth of Oxide and Nitride Nanowires and Nanobelts and Their Assembly
• Measurement of Thicknesses of High-κ Gate-Dielectric Films on Silicon
• Spectroscopic Characterization of Buried Metal/Molecule/Semiconductor Interfaces
• Generating Trace Moisture with Dilution Techniques
• Monte Carlo Simulation of Microelectronics for 3D Chemical Imaging
• Round-Robin Study of Arsenic Implant Dose Measurement in Silicon by Secondary Ion Mass Spectrometry (SIMS)
• In Situ Monitoring of Ion Bombardment Energies in Plasma Etchers for Improved Wafer Yield and Throughput
• In-Situ Ellipsometric Study of the Adsorption of Additives on Ruthenium

Measurement Science for Future Standards and Technologies

• EFTEM Spectral Imaging: A Screening Tool for the Discovery of New Nanostructures
• Charge Transport in Molecular Electronic Systems
• Development of Proteomics-Based Methods for Protein Quantification
• Microfluidic Cell-Based Analysis
• Understanding the Tandem Mass Spectrometry of Peptides
• Molecular Simulation of Alkylsilane Stationary Phases in Liquid Chromatography
• Nanobiotechnology: Nanoscale Chemical Reactions and Separations
• High Spatial Resolution Infrared Microscopy with a Solid Immersion Lens
• Properties and Processes for Cryogenic Refrigeration
• Charge Addition Effects in Phenylene Ethynylene Oligomers: The Effect of -NO2 Substitution
• Scanning Temperature Gradient Focusing
• Self-Assembly of DNA-Wrapped Carbon Nanotubes for Sensing Applications
• Injection Barriers of Molecular Wires
• Importance of Single-Strand DNA Conformational Changes in the Determination of DNA Duplex Stability

Measurement Standards

• Traceable Calibrations Gases: SRMs, NTRMs, and Protocol Gases
• A Suite of CCQM Studies to Critically Evaluate the Overall Variability in the Analysis of PCB Congeners in Tissue
• International Equivalence of Thermometry Calibrations
• Characterization of Chemical Properties, Unit Cell Parameters and Particle Size Distribution of Three Zeolite Reference Materials

Pharmaceuticals and Biomanufacturing

• Universal Data Model for Harvesting and Exchange of NMR Results
• Metrology for Quantitative Cell Biology
• Class IV Adenylyl Cyclase Structure Determination
• Enzymes in the Pathway for Production of Aromatic Hydrocarbons
• Quantitative Optical Spectroscopy of Biologicals
• Structural Analysis of the Telomerase RNA Pseudoknot Domain by Raman Spectroscopy
• Measurement of Structural and Dynamic Changes in G-Proteins in Signal Transduction
• Thermodynamics of Ketoreductase-Catalyzed Reactions in Non-aqueous Media
• Proteomics: Quantification of Human Neutrophil Peptides by Mass Spectrometry
• Protein Measurements on Surfaces