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Sponsors:

	Biotechnology Division (NIST Chemical Science and Technology Laboratory)
	Division of Cancer Biology (NCI)

Description:

The health care community, particularly the clinical diagnostics community, is moving towards a systems biology or proteomic approach to disease detection and diagnosis. A broad set of human health issues relate to mitochondrial function, from the biology of cancer development to issues relating to homeland security that include bioterrorism and chemical toxicities.  Mitochondrial proteins are encoded by both nuclear and mitochondrial genes, making the human mitochondrial proteome a good candidate for an integrated systems biology/proteomics model system. The human mitochondrion is central to basic life functions for the generation of cellular energy, and as such is the site of key components of the biosynthetic pathways, as well as the cellular decision points leading to apoptosis (programmed cell death), and other important functions. The mitochondrion represents a discrete subcellular organelle with a non-nuclear genome that is comprised of about 1000 or more different protein species with tissue-specific features. Thus, the focus of this workshop will be to provide:

• Assessment of the mitochondrion as an integrated model for systems biology studies
• Assessment of emerging proteomics technologies
• Identification of the standards needs for proteomic applications in the clinical diagnostics industry
• Guidance for determination of appropriate data elements (Common Data Elements, CDEs) for health care proteomics

Who Should Attend:

Industrial, academic and government researchers interested in the applied and fundamental aspects and recent developments and future direction in the areas of proteomics and human mitochondrial disease impacts on health care, including homeland security and bioterrorism and chemical terrorism.

This meeting is planned to be a highly interactive discussion (in a “between speakers and attendees” sense, not in a computer sense) on proteomics in general, mitochondrial proteomics in particular, and how NIST can serve the industry.  Speakers will emphasize the role that NIST can play in their subdiscipline. (All titles of talks are not yet confirmed).