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Nuclear magnetic resonance (NMR) techniques are being applied to determine the structure and dynamics of proteins, nucleic acids and protein-nucleic acids complexes in solution. Efforts include the development of new multi-dimensional heteronuclear NMR methods for resonance assignment, J-coupling constant and residual dipolarcoupling determination, and ligand screening. High-resolution structures and information about macromolecular dynamics determined using NMR methods are being applied to accelerate the discovery of novel therapeutics that target retroviral RNA.
Contacts: John Marino
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