Miral Dizdaroglu

Doctor of Natural Sciences (Dr. rer. nat.)
Doctor Honoris Causa
NIST Fellow
Group Leader

NIST Building 227, Room A243
100 Bureau Drive
Gaithersburg, MD 20899-8311 USA
Phone: 301-975-2581
E-mail: miral.dizdar@nist.gov

Miral Dizdaroglu

 

Education

  • Diploma in Chemical Engineering, University of Ankara, Turkey, 1967. 

  • Doctorate (Dr. rer. nat.) in Physical Chemistry at the University of Karlsruhe, W. Germany, 1971

Current Research

  • Oxidative Stress / DNA Damage and DNA Repair


Oxidative Stress / DNA Damage and DNA Repair

     Oxidative stress is produced in cells by oxygen-derived species resulting from cellular metabolism and from interaction with cells of exogenous sources such as carcinogenic compounds, redox-cycling drugs and ionizing radiations. DNA damage caused by oxygen-derived species including free radicals is the most frequent type encountered by aerobic cells. When this type of damage occurs to DNA, it is called oxidative DNA damage and it can produce a multiplicity of modifications in DNA including base and sugar lesions, strand breaks, DNA-protein cross-links and base-free sites. Accurate measurement of these modifications is essential for understanding of mechanisms of oxidative DNA damage and its biological effects. Numerous DNA lesions have been identified in cells and tissues at steady-state levels and upon exposure to free radical-generating systems. Data accumulated over many years clearly show that oxidative DNA damage plays an important role in a number of disease processes. Thus, oxidative DNA damage is implicated in carcinogenesis and neurodegenerative diseases such as Alzheimer’s disease. There is also strong evidence for the role of this type of DNA damage in the aging process. The accumulation of oxidative DNA damage in non-dividing cells is thought to contribute to age-associated diseases. DNA damage is countered in cells by DNA repair, which is a basic and universal process to protect the genetic integrity of organisms. The genomes of organisms encode DNA repair enzymes that continuously monitor chromosomes to correct DNA damage. Multiple processes such as base- and nucleotide-excision pathways exist to repair the wide range of DNA damages. If left unrepaired, oxidative DNA damage can lead to detrimental biological consequences in organisms, including cell death, mutations and transformation of cells to malignant cells. Therefore, DNA repair is regarded as one of the essential events in all life forms. There is an increasing awareness of the importance of oxidative DNA damage and its repair to human health. Thus, it becomes exceedingly important to understand, at the fundamental level, the mechanisms of oxidative DNA damage, and its processing by DNA repair enzymes as well as how unrepaired DNA lesions may lead to cytotoxicity, mutagenesis and eventually to diseases and aging. More detailed knowledge of mechanisms of DNA damage and repair might allow us to modulate DNA repair. This could lead to drug developments and clinical applications including the improvement of cancer therapy by inhibiting DNA repair in drug- or radiation-resistant tumors and/or the increase in the resistance of normal cells to DNA damage by overexpressing DNA repair genes.

APPOINTMENTS HELD

October 2006-present
NIST Fellow, National Institute of Standards and Technology, Gaithersburg, MD

October 2000-present
Group Leader, DNA Measurements Group, Biochemical Science Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD

1990-present
Adjunct Professor, University of Maryland Baltimore County, Baltimore, MD

May 1986-present
Senior Scientist, DNA Measurements Group, Biochemical Science Division , Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD

1984-1986
Adjunct Professor, University of Maryland Baltimore County, Baltimore, MD

1983-1984
National Foundation for Cancer Research, Bethesda, MD

1980-1983
Visiting Associate Professor, University of Maryland Baltimore County, Baltimore, MD

1978-1980
Visiting Scientist at the US Army Natick R & D Command, Natick, MA

1971-1978
Research Scientist at the Max-Planck-Institute for Radiation Chemistry, Mülheim a.d. Ruhr, W. Germany

1968-1971
Research Student at the Nuclear Research Center, Karlsruhe, W. Germany

SCIENTIFIC AWARDS
Hillebrand Prize of the Washington DC Section of the American Chemical Society, 1989

Science Award of the Scientific and Technological Research Council of the Republic of  Turkey, 1993

Silver Medal Award of the United States Department of Commerce, 1993

Turkish-American of the Year for Excellence in Science Award of the Assembly of the Turkish-American Associations in the USA, 1993

Doctor Honoris Causa (Honorary Doctorate) from Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland, 2000

Outstanding Achievement in Science Award of the Assembly of the Turkish-American Associations in the USA, 2001

Gold Medal Award of the United States Department of Commerce, 2005

JOURNAL EDITORSHIP
Member of the Editorial Board of Free Radical Biology & Medicine
Past Member of the Editorial Board of Free Radical Research
Guest Editor of Free Radical Biology & Medicine for Serial Reviews entitled "Oxidative DNA Damage and Repair."

CONFERENCE
Organizer and Director of the NATO Advanced Study Institute on "DNA Damage and Repair; Oxygen Radical Effects, Cellular Protection and Biological Consequences," held on October 13-24, 1997 in Antalya, Turkey.

Organizer and Chairperson of the “IXth International Workshop on Radiation Damage to DNA” held on May 13-17, 2006 in Antalya, Turkey.

PUBLICATIONS

Text Book

Editor of "Advances in DNA Damage and Repair; Oxygen Radical Effects, Cellular Protection and Biological Consequences", Kluwer Academic / Plenum Publishers, New York, 1999.

Papers Published in Peer-Reviewed Journals and Books

  1. Dizdaroglu M., Scherz, H., and von Sonntag, C., "g-Radiolysis of meso-Erythritol in Aqueous Solution,"  Z. Naturforsch. 27b, 29-41, 1972.

  2. von Sonntag, C., and Dizdaroglu, M., "Radical Chain Reactions in Crystalline alpha-Lactose Monohydrate,"  Z. Naturforsch. 28b, 367-368, 1973.

  3. Dizdaroglu, M., von Sonntag, C., Schulte-Frohlinde, D., and Dahlhoff, W.V., "Radiation Chemical Preparation of 5-Deoxylactobionic Acid,"  Liebigs Ann. Chem. 1592-1594, 1973.

  4. Dizdaroglu, M., and von Sonntag, C., "g-Radiolysis of Cellobiose in N2O-saturated Aqueous Solution, Part I. Identification of the Products,"  Z. Naturforsch. 28b, 635-646, 1973.

  5. Dizdaroglu, M., Henneberg, D., and von Sonntag, C., "The Mass Spectra of TMS-Ethers of Deuterated Polyalcohols.  A contribution to the Structural Investigation of Sugars," Org. Mass Spectr. 8, 335-345, 1974.

  6. von Sonntag, C., Neuwald, K., and Dizdaroglu, M., "g-Radiolysis of 2-Deoxy-D-Ribose in the Crystalline State.  Conversion of 2-Deoxy-D-Ribose into 2,5-Deoxy-D-erythro-pentonic Acid via a Chain Reaction,"  Radiat. Res. 58, 1-8, 1974.

  7. Dizdaroglu, M., Henneberg, D., Schomburg, G., and von Sonntag, C., "g-Radiolysis of Glucose in Deoxygenated N2O Saturated Aqueous Solution,"  Z. Naturforsch.  30b, 416-424, 1975.

  8. Dizdaroglu, M., von Sonntag, C., and Schulte-Frohlinde, D., "Strand Breaks and Sugar Release by g-Irradiation of DNA in Aqueous Solution,"  J. Amer. Chem. Soc. 97, 2277-2278 (1975).

  9. Dizdaroglu, M., Schulte-Frohlinde, D., and von Sonntag, C., "Strand Breaks and Sugar Release by g-Irradiation of DNA in Aqueous Solution.  The Effect of Oxygen,"  Z. Naturforsch. 30c, 826-828, 1975.

  10. Dizdaroglu, M., Leitich, J., and von Sonntag, C., "Conversion of D-Fructose into 6-Deoxy-threo 2,5-hexodiulose by g-Irradiation.  A Chain Reaction in the Crystalline State,"  Carbohydr. Res., 47, 15-23, 1976.

  11. Dizdaroglu, M., Neuwald, K., and von Sonntag, C., "Radiation Chemistry of DNA Model Compounds, IX. Carbohydrate Products in the g-Radiolysis of Thymidine in Aqueous Solution. The Radical Induced Scission of the N-Glycosidic Bond,"  Z. Naturforsch. 31b, 227-233, 1976.

  12. von Sonntag, C., Dizdaroglu, M., and Schulte-Frohlinde, D., "g-Radiolysis of Cellobiose in N2O-Saturated Aqueous Solution, Part II. Quantitative Measurements.  Mechanisms of the Radical Induced Scission of the Glycosidic Linkage,"  Z. Naturforsch. 31b, 857-864, 1976.

  13. Baugh, P.J., Goodall, J.I., Phillips, G.O., von Sonntag, C., and Dizdaroglu, M., "Radiation Induced Ring Opening in Cyclic Oligosaccharide Hydrates,"  Carbohydr. Res. 49, 313-323, 1976.

  14. Dizdaroglu, M., Henneberg, D., Neuwald, K., Schomburg, G., von Sonntag, C., "g-Radiolysis of Crystalline D-Glucose and D-Fructose,"  Z. Naturforsch. 32b, 213-224, 1977.

  15. von Sonntag, C., and Dizdaroglu, M., "The Reactions of OH Radicals with D-Ribose in Deoxygenated and Oxygenated Aqueous Solution,"  Carbohydr. Res. 58, 21-30, 1977.

  16. Dizdaroglu, M., Schulte-Frohlinde, D., and von Sonntag, C., "Isolation of 2-Deoxy-D-erythro-pentonic acid from an Alkali Labile Site in g-Irradiated DNA,"  Int. J. Radiat. Biol. 32, 481-483, 1977.

  17. Dizdaroglu, M., Henneberg, D., von Sonntag, C., and Schuchmann, M.N., "Mass Spectra of Trimethylsilyl Di-O-Methyloximes of Aldosuloses and Dialdoses,"  Org. Mass Spectr. 12, 772-776, 1977.

  18. Dizdaroglu, M., Schulte-Frohlinde, D., and von Sonntag, C., "g-Radiolysis of DNA in Oxygenated Aqueous Solution. Structure of An Alkali Labile Site,"  Z. Naturforsch. 32c, 1021-1022, 1977.

  19. Dizdaroglu, W., Hermes, W., Schulte-Frohlinde, and von Sonntag, C., "Enzymatic Digestion    of DNA g-Irradiated in Aqueous Solution.  Separation of the Digests by Ion-Exchange Chromatography," Int. J. Radiat. Biol. 33, 563-569, 1978.

  20. Dizdaroglu, M., Hermes, W., von Sonntag, C., and Schott, H., "Separation of the Sequence Isomers of Pyrimidine Deoxytetranucleoside Triphosphates by High-Performance Ion-Exchange Liquid Chromatography,"  J. Chromatogr. 169, 429-435, 1979.

  21. Dizdaroglu, M., and Hermes, W., "Separation of Small DNA and RNA Oligonucleotides by High-Performance Anion-Exchange Liquid Chromatography,"  J. Chromatogr. 171, 321-330, 1979.

  22. Beesk, F., Dizdaroglu, M, Schulte-Frohlinde, D., and von Sonntag, C., "Radiation Induced DNA Strand Breaks in Deoxygenated Aqueous Solution.  The Formation of Altered Sugars as End Groups,"  Int. J. Radiat. Biol. 36, 565-577, 1979.

  23. Dizdaroglu, M., Simic, M.G., and Schott, H., "Separation and Sequencing of the Sequence Isomers of Pyrimidine Deoxypentanucleoside Tetraphosphates by High-Performance Liquid Chromatography,"  J. Chromatogr. 188, 273-279, 1980.

  24. Dizdaroglu, M., and Simic, M.G., "Separation of Underivatized Dipeptides by High-Performance Liquid Chromatography on a Weak Anion-Exchange Bonded Phase,"  J. Chromatogr. 195, 119-126, 1980.

  25. Dizdaroglu, M., and Simic, M.G., "Separation of Dipeptides by High-Resolution Gas Chromatography on a Fused Silica Capillary Column After Trimethylsilylation,"  Anal. Biochem. 108, 269-273, 1980.

  26. Dizdaroglu, M., and Simic, M.G., "Hydroxycyclodienyl Peroxy Radicals,"  Oxygen Radicals in Chemistry and Biology, Eds. M.A.J. Rodgers and E.L. Powers, pp. 619-621, Academic Press, New York, 1981.

  27. Dizdaroglu, M., Krutzsch, H.C., and Simic, M.G, "Separation of Peptides by High Performance Liquid Chromatography on a Weak Anion-Exchange Bonded Phase,"  J. Chromatogr. 237, 417-428, 1982.

  28. Dizdaroglu, M., and Simic, M.G., "Separation of Dipeptide Diastereomers by High-Resolution Gas Chromatography,"  J. Chromatogr. 244, 293-298, 1982.

  29. Dizdaroglu, M., Krutzsch, H.C., and Simic, M.G., "Separation of Angiotensins by High-Performance Liquid Chromatography on a Weak Anion-Exchange Bonded Phase,"  Anal. Biochem. 123, 190-193, 1982.

  30. Dizdaroglu, M., Simic, M.G., Rioux, R., and St-Pierre, S., "Separation of Diastereomers and Analogues of Neurotensin by Anion-Exchange High-Performance Liquid Chromatography," J. Chromatogr. 245, 158-162, 1982.

  31. Gajewski, E., Dizdaroglu, M., and Simic, M.G. "Kovats Indices of Trimethylsilylated Amino Acids on Fused Silica Capillary Columns,"  J. Chromatogr. 249, 41-55, 1982.

  32. Dizdaroglu, M., Gajewski, E., Simic, M.G., and Krutzsch, H.C., "Identification of Some OH Radical-Induced Products of Lysozyme,"  Int. J. Radiat. Biol. 43, 185-193, 1983.

  33. Dizdaroglu, M., and Krutzsch, H.C., "Comparison of Reversed-Phase and Weak Anion-Exchange High-Performance Liquid Chromatographic Methods for Peptide Separations,"  J. Chromatogr. 264, 223-229, 1983.

  34. Simic, M.G., Dizdaroglu, M., and DeGraf, E., "Radiation Chemistry - Extravaganza or an Integral Component of Radiation Processing of Food,"  Radiat. Phys. Chem. 22, 233-239, 1983.

  35. Dizdaroglu, M., and Simic, M.G., "Isolation and Characterization of Radiation-Induced Aliphatic Peptide Dimers,"  Int. J. Radiat. Biol. 44, 231-239, 1983.

  36. Dizdaroglu, M. (invited paper), "Separation of Peptides by High-Performance Ion-Exchange Chromatography,"  in Handbook of HPLC for the Separation of Amino Acids, Peptides and Proteins, Ed., W.S. Hancock, Vol. II, pp. 23-44, CRC Press, Baco Raton, 1984.

  37. Neta, P., Dizdaroglu, M., and Simic, M.G., "Radiolytic Studies of the Cumyloxyl Radical In Aqueous Solutions,"  Israel J. Chem. 24, 25-28, 1984.

  38. 38. Dizdaroglu, and Simic, M.G. "Radiation-Induced Formation of Thymine-Thymine Crosslinks," Int. J. Radiat. Biol. 46, 241-246, 1984.

  39. Dizdaroglu, M., Gajewski, E., and Simic, M.G., "Enzymatic Digestibility of Peptides Crosslinked by Ionizing Radiation,"  Int. J. Radiat. Biol. 45, 283-295, 1984.

  40. Gajewski, E., Dizdaroglu, M., Krutzsch, H.C., and Simic, M.G., "OH Radical-Induced Crosslinks of Methionine Peptides,"  Int. J. Radiat. Biol. 46, 47-55, 1984.

  41. Dizdaroglu, M., "The Use of Capillary Gas Chromatography-Mass Spectrometry for Identification of Radiation-Induced DNA Base Damage and DNA Base-Amino Acid Crosslinks," J. Chromatogr. 295, 103-121, 1984.

  42. Dizdaroglu, M., and Simic, M.G., "Radiation-Induced Crosslinking of Cytosine,"  Radiat. Res. 100, 41-46, 1984.

  43. Karam, L.R., Dizdaroglu, M., and Simic, M.G., "OH Radical-Induced Products of Tyrosine Peptides,"  Int. J. Radiat. Biol. 46, 715-724, 1984.

  44. Dizdaroglu, M., "Separation of Sequence Isomeric Dipeptides by High-Resolution Gas Chromatography,"  J. Chromatogr. 318, 384-386, 1985.

  45. Simic, M.G., and Dizdaroglu, M., "Formation of Radiation-Induced Crosslinks between Thymine and Tyrosine:  Possible Model for Crosslinking of DNA and Proteins by Ionizing Radiation," Biochemistry 24, 233-236, 1985.

  46. Margolis, S., and Dizdaroglu, M., "Separation and Purification of Diastereomers of Angiotensin I by Anion-Exchange High-Performance Liquid Chromatography,"  J. Chromatogr. 322, 117-128, 1985.

  47. Dizdaroglu, M. "Application of Capillary Gas Chromatography-Mass Spectrometry to Chemical Characterization of Radiation-Induced Base Damage of DNA:  Implications for Assessing DNA Repair Processes,"  Anal. Biochem. 144, 593-603, 1985.

  48. Dizdaroglu, M., (invited paper), "Weak Anion-Exchange High-Performance Liquid Chromatography of Peptides,"  J. Chromatogr. Chrom. Rev. 334, 49-69, 1985.

  49. Dizdaroglu, M., and Simic, M.G., "Radiation-Induced Crosslinks Between Thymine and Phenylalanine."  Int. J. Radiat. Biol. 47, 63-69, 1985.

  50. Simic, M.G., Gajewski, E., and Dizdaroglu, M., "Kinetics and Mechanisms of Hydroxyl Radical-Induced Crosslinks Between Phenylalanine Peptides,"  Radiat. Phys. Chem. 24, 465-473, 1985.

  51. Dizdaroglu, M., "Formation of an 8-Hydroxyguanine Moiety in Deoxyribonucleic Acid on g-Irradiation in Aqueous Solution,"  Biochemistry 24, 4476-4481, 1985.

  52. Dizdaroglu, M., and Simic, M.G., "Radiation-Induced Crosslinking of Pyrimidine Oligonucleotides,"  Radiat. Phys. Chem. 26, 309-316, 1985.

  53. Karam, L.R., Simic, M.G., and Dizdaroglu, M., "Free Radical-Induced Crosslinking of Polydeoxythymidylic Acid in Deoxygenated Aqueous Solution,"  Int. J. Radiat. Biol. 49, 67-75, 1986.

  54. Dizdaroglu, M., Holwitt, E., Hagan, M.P., and Blakely, W.F., "Formation of Cytosine Glycol and 5,6-Dihydroxycytosine in Deoxyribonucleic Acid on Treatment with Osmium Tetroxide," Biochem. J. 235, 531-536, 1986.

  55. Dizdaroglu, M., and Bergtold, D.S., "Characterization of Free Radical-Induced Base Damage in DNA at Biologically Relevant Levels,"  Anal. Biochem. 156, 182-188, 1986.

  56. Dizdaroglu, M., "Free Radical-Induced Formation of an 8,5'-Cyclo-2'-deoxyguanosine Moiety in Deoxyribonucleic Acid,"  Biochem. J. 238, 247-254, 1986.

  57. Dizdaroglu, M., "Characterization of Free Radical-Induced Base Damage in DNA by the Combined Use of Enzymatic Hydrolysis and Gas Chromatography-Mass Spectrometry,"  J. Chromatogr. 367, 357-366, 1986.

  58. Dizdaroglu, M., (invited paper), "Chemical Characterization of Ionizing Radiation-Induced Damage to DNA,"  BioTechniques 4, 536-546, 1986.

  59. Dizdaroglu, M., Dirksen, M.L., Jiang, H., and Robbins, J.H., "Ionizing Radiation-Induced Damage in the Deoxyribonucleic Acid of Cultured Human Cells: Identification of 8,5'-Cyclo-2'-deoxyguanosine,"  Biochem. J. 241, 929-932, 1987.

  60. Dizdaroglu, M., (invited paper), "Measurement and Significance of Free Radical Damage to DNA,"  in Free Radicals: Methodology and Concepts, Eds., C. Rice-Evans and B. Halliwell, pp. 123-138, Richelieu Press, London, 1988.

  61. Dirksen, M.-L., Blakely, W.F., Holwitt, E., and Dizdaroglu, M., "Effect of DNA Conformation on the Hydroxyl Radical-Induced Formation of 8,5'-Cyclopurine 2'-Deoxyribonucleoside Residues in DNA,"  Int. J. Radiat. Biol. 54, 195-204, 1988.

  62. Margolis, S.A., Coxon, B., Gajewski, E., and Dizdaroglu, M., "Structure of a Hydroxyl Radical-Induced Crosslink of Thymine and Tyrosine,"  Biochemistry 27, 6353-6359, 1988.

  63. Gajewski, E., Fuciarelli, A.F., and Dizdaroglu, M., "Structure of Hydroxyl Radical-Induced DNA-Protein Crosslinks in Calf Thymus Nucleohistone in vitro,"  Int. J. Radiat. Biol. 54, 445-459, 1988.

  64. Karam, L.R., Dizdaroglu, M., and Simic, M.G., "Intramolecular H Atom Abstraction from the Sugar Moiety by Thymine Radicals in Oligo- and Polydeoxynucleotides,"  Radiat. Res. 116, 210-216, 1988.

  65. Dizdaroglu, M., (invited paper), "Chemical Determination of Oxidative Damage to DNA,"  in Handbook of Free Radicals and Antioxidants in Biomedicine, Eds., J. Miquel, A.T. Quintanilha and H. Weber, Vol. III, pp. 153-166, CRC Press, Baco Raton, 1989.

  66. Dizdaroglu, M., Gajewski, E., Reddy, P., and Margolis, S.A., "Structure of a Hydroxyl Radical-induced DNA-Protein Crosslink involving Thymine and Tyrosine in Nucleohistone,"  Biochemistry 28, 3625-3628, 1989.

  67. Neta, P., and Dizdaroglu, M., (invited paper), "Radiation Chemistry of Enones,"  in Chemistry of Enones, Eds., S. Patai and Z. Rappaport, pp. 757-780, J. Wiley & Sons Ltd., New York, 1989.

  68. Dizdaroglu, M., and Gajewski, E., "Structure and Mechanism of Hydroxyl Radical-induced Formation of a DNA-Protein Cross-Link Involving Thymine and Lysine in Nucleohistone," Cancer Research 49, 3463-3467, 1989.

  69. Fuciarelli, A.F., Wegher, B.J., Gajewski, E., Dizdaroglu, M., and Blakely, W.F., "Quantitative Measurement of Radiation-induced Base Products in DNA Using Gas Chromatography-Mass Spectrometry,"  Radiat. Res. 119, 219-231, 1989.

  70. Aruoma, O.I., Halliwell, B., and Dizdaroglu, M., "Iron Ion-Dependent Modification of Bases in DNA by the Superoxide Radical-Generating System Hypoxanthine/Xanthine Oxidase,"  J. Biol. Chem. 264, 13024-13028, 1989.

  71. Jackson, J.H., Gajewski, E.,  Schraufstatter, I.U., Hyslop, P.A., Fuciarelli, A.F., Cochrane, C.G., and Dizdaroglu, M., "Damage to the Bases in DNA by Stimulated Human Neutrophils," J. Clin. Invest. 84, 1644-1649, 1989.

  72. Aruoma, O.I., Halliwell, B., Gajewski, E., and Dizdaroglu, M., "Damage to the Bases in DNA Induced by Hydrogen Peroxide and Ferric Ion Chelates,"  J. Biol. Chem. 264, 20509-20512 (1989).

  73. Gajewski, E., and Dizdaroglu, M., "Hydroxyl Radical-Induced Cross-linking of Cytosine and Tyrosine in Nucleohistone,"  Biochemistry 29, 977-980, 1990.

  74. Dizdaroglu, M., and Gajewski, E. (invited paper), "Selected-Ion Mass Spectrometry: Assays of Oxidative DNA Damage,"  Methods in Enzymology, 186, 530-544, 1990.

  75. Blakely, W.F., Fuciarelli, A.F., Wegher, B.J., and Dizdaroglu, M., "Hydrogen peroxide-Induced Base Damage in Deoxyribonucleic Acid,"  Radiat. Res. 121, 338-343, 1990.

  76. Wood, M.L., Dizdaroglu, M., Gajewski, E., and Essigmann, J.M., "Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome,"  Biochemistry 29, 7024-7032, 1990.

  77. Gajewski, E., Rao, G., Nackerdien, Z., and Dizdaroglu, M., "Modification of DNA Bases in Mammalian Chromatin by Radiation-Generated Free Radicals,"  Biochemistry 29, 7876-7882, 1990.

  78. Dizdaroglu, M., (invited paper), "Measurement of DNA Base Damage and Protein Cross-links in Mammalian Chromatin,"  in Ionizing Radiation Damage to DNA: Molecular Aspects, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 136, pp. 17-30, 1990.

  79. Dizdaroglu, M., Aruoma, O.I., and Halliwell, B., "Modification of the Bases in DNA by Copper Ion-1,10-Phenanthroline Complexes,"  Biochemistry 29, 8447-8451, 1990.

  80. Fuciarelli, A.F., Wegher, B.J., Blakely, W.F., and Dizdaroglu, M., "Yields of Radiation-Induced Base Products in DNA. Effects of DNA Conformation and Gassing Conditions,"  Int. J. Radiat. Biol. 58, 397-415, 1990.

  81. Akman, S.A., Doroshow, J.H., and Dizdaroglu, M., "Base Modifications in Plasmid DNA Caused by Potassium Permanganate,"  Arch. Biochem. Biophys. 282, 202-205, 1990.

  82. Dizdaroglu, M., (invited paper), "Gas Chromatography-Mass Spectrometry of Free Radical-Induced Products of Pyrimidines and Purines in DNA,"  Methods in Enzymology 193, 842-857, 1990.

  83. Dizdaroglu, M., (invited paper), "The Purification of Polypeptide Samples by Ion-Exchange Chromatography on Silica-Based Supports,"  in High-Performance Liquid Chromatography in Biotechnology, Ed., W. S. Hancock, pp. 263-278, J. Wiley & Sons, New York, 1990.

  84. Aruoma, O.I., Halliwell, B., Gajewski, E., and Dizdaroglu, M., "Copper Ion-Dependent Damage to the Bases in DNA by Hydrogen Peroxide,"  Biochem. J. 273, 601-604, 1991.

  85. Dizdaroglu, M., Rao, G., Halliwell, B., and Gajewski, E., "Damage to the Bases in Mammalian Chromatin by Hydrogen Peroxide in the Presence of Ferric and Cupric Ions,"  Arch. Biochem. Biophys. 285, 317-324, 1991.

  86. Dizdaroglu, M., Nackerdien, Z., Chao, B.C., Gajewski, E., and Rao, G., "Chemical Nature of in vivo DNA Base Damage in Hydrogen Peroxide-Treated Mammalian Cells,"  Arch. Biochem. Biophys. 285, 388-390, 1991.

  87. Gajewski, E., Aruoma, O. I., Dizdaroglu, M., and Halliwell, B., "Bleomycin-dependent Damage to the Bases in DNA is a Minor Reaction,"  Biochemistry 30, 2444-2448, 1991.

  88. Dizdaroglu, M., (invited paper), "Chemical Determination of Free Radical-induced Damage to DNA,"  Free Radic. Biol. Med. 10, 225-242, 1991.

  89. Nackerdien, Z., Rao, G., Cacciuttolo, M. A., Gajewski, E., and Dizdaroglu, M., "Chemical Nature of DNA-Protein Cross-links Produced in Mammalian Chromatin by Hydrogen Peroxide in the Presence of Iron or Copper Ions,"  Biochemistry 30, 4873-4879, 1991.

  90. Akman, S. A., Forrest, G. P., Doroshow, J. H., and Dizdaroglu, M., "Mutation of Potassium Permanganate and Hydrogen Peroxide-Treated Plasmid pZ189 Replicating in CV-1 Monkey Kidney Cells,"  Mutat. Res. 261, 123-130, 1991.

  91. Nackerdien, Z., Kasprzak, K. S., Rao, G., Halliwell, B., and Dizdaroglu, M., "Nickel(II)- and Cobalt(II)-dependent Damage by Hydrogen Peroxide to the DNA Bases in Isolated Human Chromatin,"  Cancer Res. 51, 5837-5842, 1991.

  92. Boiteux, S., Gajewski, E., Laval, J., and Dizdaroglu, M., "Substrate Specificity of the Escherichia Coli Fpg Protein (Formamidopyrimidine-DNA Glycosylase): Excision of Purine Lesions in DNA Produced by Ionizing Radiation or Photosensitization,"  Biochemistry 31, 106-110, 1992.

  93. Dizdaroglu, M., (invited paper), "Measurement of Radiation-Induced Damage to DNA at the Molecular Level,"  Int. J. Radiat. Biol. 61, 175-183, 1992.

  94. Halliwell, B., and Dizdaroglu, M., "Commentary: The Measurement of Oxidative Damage to DNA by HPLC and GC/MS Techniques,"  Free Radic. Res. Commun. 16, 75-87, 1992.

  95. Akman, S. A., Doroshow, J. H., Burke, T. G., and Dizdaroglu, M., "DNA Base Modifications Induced in Isolated Human Chromatin by NADH Dehydrogenase-Catalyzed Reduction of Doxorubicin,"  Biochemistry 31, 3500-3506, 1992.

  96. Nackerdien, Z., Olinski, R., and Dizdaroglu, M., "DNA Base Damage in Chromatin of g-Irradiated Cultured Human Cells,"  Free Radic. Res. Commun. 16, 259-272, 1992.

  97. Olinski, R., Nackerdien, Z., and Dizdaroglu, M., "DNA-Protein Cross-linking Between Thymine and Tyrosine in Chromatin of g-Irradiated or H2O2-Treated Cultured Human Cells,"  Archiv. Biochem. Biophys. 297, 139-143, 1992.

  98. Olinski, R., Zastawny, T., Budzbon, J., Skokowski, J., Zegarski, W., and Dizdaroglu, M., "DNA Base Modifications in Chromatin of Human Cancerous Tissues,"  FEBS Lett. 309, 193-198, 1992.

  99. Dizdaroglu, M., (invited paper), "Oxidative Damage to DNA in Mammalian Chromatin,"  Mutat. Res. 275, 331-342, 1992.

  100. Kasprzak, K. S., Diwan, B. A., Rice, J. M., Misra, M., Olinski, R., and Dizdaroglu, M., "Nickel(II)-Mediated Oxidative DNA Base Damage in Rat Renal Chromatin in vivo. Possible Relevance to Nickel(II) Carcinogenesis,"  Chem. Res. Toxicol. 5, 809-815, 1992.

  101. Dizdaroglu, M.,  "Quantitative Determination of Oxidative Base Damage in DNA by Stable Isotope-Dilution Mass Spectrometry,"  FEBS Lett. 315, 1-6, 1993.

  102. Misra, M., Olinski, R., Dizdaroglu, M., and Kasprzak, K. S., "Enhancement by L-Histidine of  Nickel (II)-Induced DNA-Protein Cross-Linking and Oxidative DNA Base Damage in the Rat Kidney," Chem. Res. Toxicol. 6, 33-37, 1993.

  103. Dizdaroglu, M., Olinski, R., Doroshow, J. H., and Akman, S. A., "Modification of DNA Bases in Chromatin of Intact Target Human Cells by Activated Human Polymorphonuclear Leukocytes," Cancer Res. 53, 1269-1272, 1993.

  104. Dizdaroglu, M., (invited paper), "Chemistry of Free Radical Damage to DNA and  Nucleoprotein,"  in DNA and Free Radicals, Edited by B. Halliwell and O. I. Aruoma, Ellis   Horwood, London, pp. 19-39, 1993.

  105. Akman, S. A., Kensler, T., W., Doroshow, J. H., and Dizdaroglu, M., "Copper Ion-Mediated Modification of DNA Bases in vitro by Benzoyl Peroxide,"  Carcinogenesis 14, 1971-1974, 1993.

  106. Dizdaroglu, M., Laval, J., and Boiteux, S., "Substrate Specificity of Escherichia coli Endonuclease III: Excision of Thymine- and Cytosine-Derived Lesions in DNA Produced by Radiation-Generated Free Radicals,"  Biochemistry 32, 12105-12111, 1993.

  107. Mori, T., Hori, Y., and Dizdaroglu, M., "DNA Base Damage Generated in vivo in Hepatic Chromatin of Mice Upon Whole Body g-Irradiation,"  Int. J. Radiat. Biol. 64, 645-650, 1993.

  108. Gommers-Ampt, J. H., Van Leeuwen, F., de Beer, A. L. J., Vliegenthart, J. F. G., Dizdaroglu, M., Kowalak, J. A., Crain, P. F., and Borst, P., "b-D-Glucosyl-hydroxymethyluracil: a Novel Modified Base Present in the DNA of the Parasitic Protozoan Trypanosoma brucei,"  Cell 75, 1129-1136, 1993.

  109. Dizdaroglu, M., (invited paper), "Chemical Determination of Oxidative DNA Damage by Gas Chromatography-Mass Spectrometry,"  Methods Enzymol. 234, 3-16, 1994.

  110. Toyokuni, S., Mori, T., and Dizdaroglu, M., "DNA Base Modifications in Renal Chromatin of Wistar Rats Treated with a Renal Carcinogen, Ferric Nitrilotriacetate,"  Int. J. Cancer 57, 123-128, 1994.

  111. Jaruga, P., Zastawny, T. H., Skokowski, J., Dizdaroglu, M., and Olinski, R., "Oxidative DNA Base Damage and Antioxidant Enzyme Activities in Human Lung Cancer,"  FEBS Lett. 341, 59-64, 1994.

  112. Altman, S. A., Zastawny, T. H., Randers, L., Remacle, J., Dizdaroglu, M., and Rao, R., "tertButyl Hydroperoxide-mediated DNA Base Damage in Cultured Mammalian Cells,"  Mutat. Res. 306, 35-44, 1994.

  113. Kasprzak, K. S., Zastawny, T. H., North, S. L., Riggs, C. W., Diwan, B. A., Rice, J. M., and Dizdaroglu, M., "Oxidative DNA Base Damage in Renal, Hepatic, and Pulmonary Chromatin of Rats After Intraperitoneal Injection of Cobalt(II) Acetate,"  Chem. Res. Toxicol. 7, 329-335, 1994.

  114. Mori, T., and Dizdaroglu, M., "Ionizing Radiation Causes Greater DNA Base Damage in Radiation-sensitive Mutant M10 Cells Than in Parent Mouse Lymphoma L5178Y Cells,"  Radiat. Res. 140, 85-90, 1994.

  115. Doetsch, P. W., Zastawny, T. H., Martin, A. M. and Dizdaroglu, M., "Monomeric Base Damage Products from Adenine, Guanine, and Thymine Induced by Exposure of DNA to Ultraviolet Radiation," Biochemistry 34, 737-742, 1995.

  116. Olinski, R., Zastawny, T. H., Foksinski, M., Barecki, A., and Dizdaroglu, M., "DNA Base Modifications and Antioxidant Enzyme Activities in Human Benign Prostatic Hyperplasia,"  Free Radic. Biol. Med. 18, 807-813, 1995.

  117. Zastawny, T. H., Altman, S. A., Randers-Eichhorn, L., Madurawe, R., Lumpkin, J. A., Dizdaroglu, M., and Rao, R., "DNA Base Modifications and Membrane Damage in Cultured Mammalian Cells Treated with Iron Ions,"  Free Radic. Biol. Med. 18, 1013-1022, 1995.

  118. Zastawny, T. H., Doetsch, P. W., and Dizdaroglu, M., "A Novel Activity of Uracil DNA N-Glycosylase: Excision of Isodialuric Acid (5,6-Dihydroxyuracil) from DNA, a Major Product of Oxidative DNA Damage," FEBS Lett. 364, 255-260, 1995.

  119. Toyokuni, S., Mori, T., Hiai, H. and Dizdaroglu, M., "Treatment of Wistar Rats with a Renal Carcinogen, Ferric Nitrilotriacetate Causes DNA‑Protein Cross-Linking between Thymine and Tyrosine in Renal Chromatin," Int. J. Cancer 62, 309-313, 1995.

  120. Altman, S. A., Zastawny, T. H., Randers-Eichhorn, L., Cacciuttolo, M., A., Lumpkin, J. A., Akman, S. A., Dizdaroglu, M., and Rao, R., "Formation of DNA-Protein Cross-links in Cultured Mammalian Cells upon Treatment with Iron Ions,"  Free Radic. Biol. Med. 19, 897-902, 1995.

  121. Dizdaroglu, M., Zastawny, T. H., Carmical, J. R. and Lloyd, R. S., "A Novel DNA N-Glycosylase Activity of E. coli T4 Endonuclease V that Excises 4,6-Diamino-5-formamido-pyrimidine from DNA, a UV-Radiation- and Hydroxyl Radical-induced Product of Adenine,"  Mutat. Res. 362, 1-8, 1996.

  122. Dizdaroglu, M., Karakaya, A., Jaruga, P., Slupphaug, G. and Krokan, H. E., "Novel Activities of Human Uracil DNA N-Glycosylase for Cytosine-Derived Products of Oxidative DNA Damage,"  Nucl. Acids Res. 24, 418-422, 1996.

  123. Höss, M., Jaruga, P., Zastawny, T. H., Dizdaroglu, M., and Pääbo, S., "DNA Damage and DNA Sequence retrieval from Ancient Tissues,"  Nucl. Acids Res. 24, 1304-1307, 1996.

  124. Jaruga, P., and Dizdaroglu, M., "Repair of Products of Oxidative DNA Damage in Human Cells,"  Nucl. Acids Res. 24, 1389-1394, 1996.

  125. Olinski, R., Zastawny, T. H., Foksinski, M., Windorbska, W., Jaruga, P., and Dizdaroglu, M., "DNA Base Damage in Lymphocytes of Cancer Patients Undergoing Radiation Therapy,"  Cancer Lett. 106, 207-215, 1996.

  126. Liu, P. K., Hsu, C. Y., Dizdaroglu, M., Floyd, R. A., Kow, Y. W., Karakaya, A., Rabow,  L. and Cui, J.-K. "Damage, Repair and Mutagenesis in Nuclear Genes of the Brain after Forebrain Ischemia and Reperfusion." J. Neuroscience 16, 6795-6806, 1996.

  127. Karakaya, A., Jaruga, P., Bohr, V. A., Grollman, A. P. and Dizdaroglu, M., "Kinetics of Excision of Purine Lesions from DNA by Fpg Protein,"  Nucl. Acids Res. 25, 474-479, 1997.

  128. Kasprzak, K. S., Jaruga, P., Zastawny, T. H., North, S. L., Riggs, C. W., Olinski, R., and Dizdaroglu, M., "Oxidative DNA Base Damage and Its Repair in Kidneys and Livers of Nickel(II)-treated Male F344 Rats,"  Carcinogenesis 18, 271-277, 1997.

  129. Sentürker, S., Karahalil, B., Inal, M., Yilmaz, H., Müslümanoglu, H., Gedikoglu, G., and Dizdaroglu, M., "Oxidative DNA Base Damage and Antioxidant Enzyme Levels in Childhood Acute Lymphoblastic Leukemia,"  FEBS Lett. 416, 286-290, 1997.

  130. Deutsch, W. A., Yacoub, A., Jaruga, P., Zastawny, T. H., Madden, C., and Dizdaroglu, M., "Characterization and Mechanism of Action of Drosophila Ribosomal Protein S3 DNA Glycosylase Activity for the Removal of Oxidatively Damaged DNA Bases,"  J. Biol. Chem. 272, 32857-32860, 1997.

  131. Karahalil, B., Roldán-Arjona, T.,  and Dizdaroglu, M., "Substrate Specificity of Schizosaccharomyces pombe Nth Protein for Products of Oxidative DNA Damage,"  Biochemistry 37, 590-595, 1998.

  132. Karahalil, B., Girard, P.-M., Boiteux, S.,  and Dizdaroglu, M. "Substrate Specificity of the Ogg1 Protein of Saccharomyces cerevisiae: Excision of Guanine Lesions Produced in DNA by Ionizing Radiation- or Hydrogen Peroxyde/Metal Ion-Generated Free Radicals,"  Nucl. Acids Res. 26, 1228-1232, 1998.

  133. Dizdaroglu, M., (invited paper), "Measurement of Oxidative DNA Damage Using the Technique of Gas Chromatography-Mass Spectrometry," in Methods in Aging Research, Edited by B. P. Yu, CRC Press, Baco Raton, pp. 607-620, 1998.

  134. Dizdaroglu, M., (invited paper), "Mechanisms of Free Radical Damage to DNA,"  in DNA and Free Radicals: Techniques, Mechanisms & Applications, Edited by O. I. Aruoma and B. Halliwell, OICA International, Santa Lucia and London, pp. 1-24, 1998.

  135. Sentürker, S., Auffret van der Kemp, P., You, H.-J., Doetsch, P. W., Dizdaroglu, M., and Boiteux, B., "Substrate Specificities of the Ntg1 and Ntg2 Proteins of Saccharomyces cerevisiae for Oxidized Bases are not identical," Nucl. Acids Res. 26, 5270-5276, 1998.

  136. Melov, S., Coskun, P., Patel, M., Tuinstra, R., Cottrell, B., Jun, A. S., Zastawny, T. H., Dizdaroglu, M., Goodman, S. I., Huang, T.-T., Miziorkos, H., Epstein, C. J., and Wallace, D. C., "Mitochondrial Disease in Superoxide Dismutase 2 Mutant Mice," Proc. Natl. Acad. Sci., USA 96, 846-851, 1998.

  137. Dizdaroglu, M., "Facts About the Artifacts in the Measurement of Oxidative DNA Base Damage by Gas Chromatography-Mass Spectrometry," Free Radic. Res. 29, 551-563, 1998.

  138. Dizdaroglu, M., Karahalil, B., Sentürker, S., Buckley, T. J., and Roldán-Arjona, T., "Excision of  Products of Oxidative DNA Base Damage by Human NTH1 Protein," Biochemistry 38, 243-246, 1999.

  139. Dizdaroglu, M., "Mechanisms of Oxidative DNA damage; Lesions and Their Measurement," in Advances in DNA Damage and Repair: Oxygen Radical Effects, Cellular Protection and Biological Consequences, Edited by M. Dizdaroglu and A. E. Karakaya, Plenum Publishing Corporation, pp. 67-87, 1999.

  140. Liang, R., Sentürker, S., Shi, X., Bal., W., Dizdaroglu, M., and Kasprzak, K. S., "Effects of Ni(II) and Cu(II) on DNA Interaction with the N-terminal Sequence of Human Protamine P2: Enhancement of Binding and Mediation of Oxidative DNA Strand Scission and Base Damage," Carcinogenesis 20, 893-898, 1999.

  141. Lipinski, L. J., Hoehr, N., Mazur, S. J., Dianov, G., Sentürker, S., Dizdaroglu, M., and Bohr, V. A., "Repair of Oxidative DNA Base Lesions Induced by Fluorescent Light is Defective in Xeroderma pigmentosum Group A Cells," Nucl. Acids. Res. 27, 3153-3158, 1999.

  142. Sentürker, S., Bauche, C., Laval, J., and Dizdaroglu, M., "Substrate Specificity of Deinococcus Radiodurans Fpg Protein," Biochemistry 38, 9435-9439, 1999.

  143. Sentürker, S., and Dizdaroglu, M., "The Effect of Experimental Conditions on the Levels of Oxidatively Modified Bases in DNA as Measured by Gas Chromatography-Mass Spectrometry. How Many Modified Bases Are Involved? Prepurification or Not?" Free Radic. Biol. Med. 27, 370-380, 1999.

  144. Anson, R. M., Sentürker, S., Dizdaroglu, M., and Bohr, V. A., "Measurement of Oxidatively Induced Base Lesions in Liver Nuclear and Mitochodrial DNA from Wistar Rats of Different Ages," Free Radic. Biol. Med. 27, 456-462, 1999.

  145. You, H. J., Swanson, R. L., Harrington, C., Corbett, A. H., Jinks-Robertson, S., Sentürker, S., Wallace, S. S., Boiteux, S., Dizdaroglu, M., and Doetsch, P. W., "Saccharomyces cerevisiae Ntg1p and Ntg2p: Broad Specificity N-Glycosylases for the Repair of Oxidative DNA Damage in the Nucleus and Mitochondria, Biochemistry 38, 11298-11306, 1999.

  146. Dherin, C., Radicella, J. P., Dizdaroglu, M., and Boiteux, S., "Excision of Oxidatively Damaged DNA Bases by the Human a-hOgg1 Protein and the Polymorphic a-hOgg1(Ser326Cys) Protein Which is Frequently Found in Human Populations," Nucl. Acids. Res. 27, 4001-4007, 1999.

  147. Dizdaroglu, M., Bauche, C., Rodriguez, H., and Laval, J., "Novel Substrates of Escherichia coli Nth Protein and Its Kinetics for Excision of Modified Bases from DNA Damaged by Free Radicals," Biochemistry 39, 5586-5592, 2000.

  148. Gogos, A., Jantz, D., Sentürker, S., Richardson, D., Dizdaroglu, M., and Clarke, N. D., "Assignment of Enzyme Substrate Specificity by Principal Component Analysis of Aligned Protein Sequences: An experimental test using DNA glycosylase homologues." Proteins 40, 98-105, 2000.

  149. Audebert, M., Radicella, J. P. and Dizdaroglu, M., "Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein," Nucleic Acids Res. 28, 2672-2678, 2000.

  150. Rodriguez, H., Jurado, J., Laval, J. and Dizdaroglu, M. "Comparison of the levels of 8-hydroxyguanine in DNA as measured by gas chromatography-mass spectrometry following hydrolysis of DNA by Escherichia coli Fpg protein or formic acid," Nucleic Acids Res. 28, e75, 2000.

  151. Bal, W., Liang, R., Lukszo, J., Lee, S.-H., Dizdaroglu, M.,  and Kasprzak, K. S., "Ni(II) Specifically Cleaves the C-Terminal Tail of the Major Variant of Histone H2A and Forms an Oxidative Damage-mediating Complex with the Cleaved-off Octapeptide," Chem. Res. Toxicol. 13, 616-628, 2000.

  152. Hazra, T. K., Izumi, T., Venkataraman, R., Kow, Y. W., Dizdaroglu, M. and Mitra, S., "Characterization of a novel 8-oxoguanine-DNA glycosylase in Escherichia coli and identification of the enzyme as endonuclease VIII," J. Biol. Chem. 275, 27762-27767, 2000.

  153. Dizdaroglu, M., (invited paper), "Oxidative DNA Damage and Its Potential Use for Monitoring Oxidative Stress," in Proceedings of the NATO-ASI Meeting on Human Monitoring After Environmental and Occupational Exposure to Chemical and Physical Agents, IOS Press, Amsterdam, pp. 76-85, 2000.

  154. Dherin, C., Dizdaroglu, M., Doerflinger, H., Boiteux, S. and Radicella, J. P., "Repair of oxidative DNA damage in Drosophila melanogaster: Identification and characterization of dOgg1, a second DNA glycosylase activity for 8-hydroxyguanine and formamidopyrimidines," Nucl. Acids Res. 28, 4583-4592, 2000.

  155. Dizdaroglu, M. (invited paper), "Oxidative DNA Damage; Mechanisms of Product Formation and Repair by Base-Excision Pathway," In Free Radicals in Chemistry, Biology and Medicine, Edited by T. Yoshikawa, S. Toyokuni, Y. Yamamoto and Y. Naito. OICA International Limited: London, pp. 58-76, 2000.

  156. Dizdaroglu, M., Jaruga, P., Rodriguez, H.  Measurement of 8-hydroxy-2’-deoxyguanosine in DNA by high-performance liquid chromatography-mass spectrometry: comparison with measurement by gas chromatography-mass spectrometry.  Nucleic Acids Res. 29, E12, 2001.

  157. Dizdaroglu, M., Jaruga, P., Rodriguez, H.  Identification and quantification of 8,5’-cyclo-2’-deoxyadenosine in DNA by liquid chromatography-mass spectrometry.  Free Radic. Biol. Med. 30, 774-784, 2001.

  158. Dizdaroglu, M., Burgess, S.M., Jaruga, P., Hazra, T.K., Rodriguez, H., Lloyd, R.S.  Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicals. Biochemistry 40, 12150-12156, 2001.

  159. Sidorkina, O., Dizdaroglu, M. and Laval, J., "Effect of single mutations on the specificity of Escherichia coli Fpg protein for excision of purine lesions from DNA damaged by free Radicals," Free Radic. Biol. Med. 31, 816-823, 2001.

  160. Jaruga, P., Rodriguez, H., Dizdaroglu, M.  Measurement of 8-hydroxy-2'-deoxyadenosine in DNA by liquid chromatography/mass spectrometry. Free Radic. Biol. Med. 31, 336-344, 2001.

  161. Tuo, J., Müftüoglu, M., Chen, C., Jaruga, P., Selzer, R.P., Brosh, Jr., R.M., Rodriguez, H., Dizdaroglu, M., and Bohr, V.A.  The Cockayne Syndrome group B gene product is involved in general genome base excision repair of 8-hydroxyguanine in DNA.  J. Biol. Chem. 276, 45772–45779, 2001.

  162. Burgess, S., Jaruga, P., Dodson, M. L., Dizdaroglu, M. and Lloyd, R. S. “Determination of active site residues in Escherichia coli endonuclease VIII,” J. Biol. Chem. 277, 2938–2944, 2002.

  163. Jaruga, P., Birincioglu, M., Rodriguez, H. and Dizdaroglu, M. “Mass spectrometric assays for the tandem lesion 8,5'-cyclo-2'-deoxyguanosine in mammalian DNA,” Biochemistry, 41, 3703-3711, 2002.

  164. Jaruga, P., Jabil, R., McCullough, A. K., Rodriguez, H., Dizdaroglu, M. and Lloyd, R. S., "Chlorella virus pyrimidine dimer glycosylase excises ultraviolet radiation- and hydroxyl radical-induced products 4,6-diamino-5-formamidopyrimidine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine from DNA," Photochem. Photobiol. 75, 85-91, 2002. 

  165. Hazra, T. K., Izumi, T., Boldogh, I., Imhoff, B., Kow, Y. W., Jaruga, P., Dizdaroglu, M. and Mitra, S., “Identification and characterization of a novel human DNA glycosylase for repair of modified bases in oxidatively damaged DNA,” Proc. Natl. Acad. Sci. USA 99, 3523-3528, 2002.

  166. Dizdaroglu, M., Jaruga, P., Birincioglu, M. and Rodriguez, H. “Free radical-induced damage to DNA: Mechanisms and measurement,” Free Radic. Biol. Med. 32, 1102-1115, 2002.

  167. Tuo, J., Jaruga, P., Rodriguez, H., Dizdaroglu, M. and Bohr, V. A., “The Cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA,” J. Biol. Chem. 277, 30832–30837, 2002.

  168. Dizdaroglu, M., Jaruga, P. and Rodriguez, H., "Mechanisms and measurement of oxidative DNA damage,"In Oxidative Stress and Aging: Advances in Basic Science, Diagnostics and Intervention." Edited by R. G. Cutler and H. Rodriguez, World Scientific, pp. 165-189, 2002.

  169. Morales-Ruiz, T., Birincioglu, M., Jaruga, P., Rodriguez, H., Roldan-Arjona, T. and Dizdaroglu, M., “Arabidopsis thaliana Ogg1 protein excises 8-hydroxyguanine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine from oxidatively damaged DNA containing multiple lesions,” Biochemistry, 42, 3089-3095, 2003.

  170. Tuo, J., Jaruga, P., Rodriguez, H., Bohr, V. A. and Dizdaroglu, M., “Primary fibroblasts of Cockayne syndrome patients are defective in the cellular repair of 8-hydroxyguanine and 8-hydroxyadenine resulting from oxidative stress,” FASEB J. 17, 668-674, 2003.

  171. Manderville, R. A., Calcutt, M. W., Dai, J., Park, J., Gillman, I. G., Noftle, R. E., Mohammed, A. K., Birincioglu, M., Dizdaroglu, M., Rodriguez, H. and Akman, S. A. “Stoichiometric preference in copper-promoted oxidative DNA damage by ochratoxin A,” J. Inorg. Biochem. 95, 87-96, 2003.

  172. Cooke, M. S., Evans, M. D., Dizdaroglu, M. and Lunec, J. “Oxidative DNA damage: mechanisms, mutation and disease,” FASEB J. 17, 1195-1214, 2003.

  173. Rodriguez, H., O’Connell, C., Barker, P. E., Atha, D. H., Jaruga, P., Birincioglu, M., Marino, M., McAndrew, P., and Dizdaroglu, M., “Biomarkers to detect molecular changes in tissue-engineered medical products. BioProcessing 2, 65-66, 2003.

  174. Rodriguez, H., Jaruga, P., Birincioglu, M., Barker, P.E., O’Connell, C., and Dizdaroglu, M., "Oxidative DNA damage biomarkers used in tissue engineered skin," In: Advances in Experimental Medicine and Biology. Y. Murat Elcin (Editor), Kluwer Academic-Plenum Press, pp. 129-135, 2003.

  175. O’Connell, C., Barker, P.E., Marino, M., McAndrew, P., Atha, D.H., Jaruga, P., Birincioglu, M., Dizdaroglu, M., and Rodriguez, H., "Biomarkers used to detect genetic damage in tissue engineered skin," In: Advances in Experimental Medicine and Biology. Y. Murat Elcin (Editor), Kluwer Academic-Plenum Press, pp. 137-145, 2003.

  176.  Birincioglu, M., Jaruga, P., Chowdhury, G., Rodriguez, H., Dizdaroglu, M. and Gates, K. S., “Mechanisms of DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (Tirapazamine),” J. Amer. Chem. Soc. 125, 11607-11615, 2003.

  177. Dizdaroglu, M. “Substrate specificities and excision kinetics of DNA glycosylases involved in base-excision repair of oxidative DNA damage,” Mutat. Res. 531, 109-126, 2003.

  178. Reddy, P., Jaruga, P., O’Connor, T., Rodriguez, H. and Dizdaroglu, M., “Overexpression and rapid purification of Escherichia coli formamidopyrimidine DNA glycosylase (Fpg),” Protein Expression and Purification 34, 126-133, 2004.

  179. Rodriguez, H., Jaruga, P., Birincioglu, M., Barker, P., O’Connell, C., and Dizdaroglu, M., "A comparative study of biomarkers of oxidative DNA damage used to detect free radical damage in tissue-engineered skin," Tissue Engineered Medical Products (TEMPS), E. Schutte, G. L. Picciolo and D. Kaplan (Editors), ASTM International, West Conshohocken, PA, pp. 84-89, 2004.

  180. Jaruga, P., Theruvathu, J., Dizdaroglu, M. and Brooks, P. J., “Complete release of (5¢S)-8,5¢-cyclo-2¢-deoxyadenosine from dinucleotides, oligodeoxynucleotides and DNA, and direct comparison of its levels in cellular DNA with other oxidatively induced DNA lesions,” Nucleic Acids. Res. 32, e87, 2004.

  181. Trzeciak , A. R., Simon, G. N., Jaruga, P., Lohani , A. A., Dizdaroglu, M., and Evans, M. K., “Cellular repair of oxidatively induced DNA base lesions is defective in prostate cancer cell lines, PC-3 and DU-145,” Carcinogenesis 25, 1359-1370, 2004.

  182. Evans, M. D., Dizdaroglu, M. and Cooke, M. S., “Oxidative DNA damage and disease: Induction, repair and significance,” Mutat. Res. 567, 1-61, 2004.

  183. Dizdaroglu, M., (invited paper) “Measurement of oxidative DNA damage by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry,” Sample Preparation for Hyphenated Analytical Techniques, Rosenfeld, J. M. (Editor), Blackwell Publishing CRC Press, pp. 39-51, 2004.

  184. Rodriguez, H., O’Connell, C., Barker, P. E., Atha, D. H., Jaruga, P., Birincioglu, M., Marino, M., McAndrew, P., and Dizdaroglu, M., “Measurement of DNA biomarkers for the safety of tissue-engineered medical products using artificial skin as a model,” Tissue Engineering 10, 1332-1345, 2004.

  185. Jaruga, P., Birincioglu, M., Rosenquist, T. A., and Dizdaroglu, M., “Mouse NEIL1 protein is specific for excision of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine from oxidatively damaged DNA,” Biochemistry 43, 15909-15914, 2004.

  186. Mambo, E., Chatterjee, A., Souza-Pinto, N., Mayard, S., Hogue, B. A., Hoque, M. O., Dizdaroglu, M., Bohr, V. A., and Sidransky, D., “Oxidized guanine lesions and hOGG1 activity in lung cancer,” Oncogene 24, 4496–4508, 2005.

  187. Theruvathu, J. A., Jaruga, P., Nath, R. G., Dizdaroglu, M., and Brooks, P. J., “Polyamines stimulate the formation of mutagenic 1,N2-propano-deoxyguanosine adducts from acetaldehyde,” Nucleic Acids Res. 33, 3513–3520, 2005.

  188. Dizdaroglu, M., “Base-excision repair of oxidative DNA damage by DNA glycosylases,” Mutat. Res. 591, 45-59, 2005.

  189. Hu, J., de Souza-Pinto, N. C., Haraguchi, K., Hogue, B. A., Jaruga, P., Greenberg, M. M., Dizdaroglu, M. and Bohr, V. A., “Repair of Formamidopyrimidines in DNA Involves Different Glycosylases: Role of the OGG1, NTH1 and NEIL1 Enzymes,” J. Biol. Chem. 280, 40544-40551, 2005.

  190. Egler, R., Fernandes, E., Rothermund, K., Sereika, S., Jaruga, P., Dizdaroglu, M., and Prochownik, E. V., “Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin I,” Oncogene 24, 8038-8050, 2005.

  191. Seiple, L., Jaruga, P., Dizdaroglu, M., and Stivers, J. T., “Linking uracil base excision and 5-fluorouracil toxicity in yeast,” Nucleic Acids Res. 34, 140-151, 2006.

  192. McLaren, S. H., Gao, D., Chen, L., Lin, R., Eshleman, J. R., Dawson, V., Trush, M. A., Bohr, V. A., Dizdaroglu. M., Williams, G. M, and Wei, C., “Oxidative Stress and DNA Damage-DNA Repair System in Vascular Smooth Muscle Cells in Artery and Vein Grafts,” J. Cardiothoracic-Renal Res. 1, 59-72. 2006.

  193. Malins, D. C., Jaruga, P., Stegeman, J. J., Green, V. M., Gilman, N. K., Anderson, K. M., and Dizdaroglu, M., “Biomarkers signal contaminant effects on the organs of English sole (Parophrys vetulus) from Puget Sound,” Envir. Health Perspec. 114, 823-829, 2006.

  194. Anderson, K. M., Jaruga, P., Ramsey, C. R., Gilman, N. K., Green, V. M., Rostad, S. W., Emerman, J. T., Dizdaroglu, M., and Malins, D. C., “Structural alterations in breast stromal and epithelial DNA: The influence of 8,5'-cyclo-2'-deoxyadenosine,” Cell Cycle 5, 1240-1244, 2006.

  195. Malins, D. C., Anderson, K. M., Jaruga, P., Ramsey, C. R., Gilman, N. K., Green, W. M., Rostad, S. W., Emerman, J. T. and Dizdaroglu, M., “Oxidative changes in the DNA of stroma and epithelium from the female breast: Potential implications for breast cancer,” Cell Cycle 5, 1629-1632, 2006.

  196. D’Errico, M., Parlanti, E., Teson, M., Miguel Bernardes de Jesus, B., Degan, P., Calcagnile, A., Jaruga, P., Bjoras, M., Crescenzi, M., Pedrini, A. M., Egly, J.-M., Zambruno, G., Stefanini, M., Dizdaroglu, M. and Dogliotti, E., “New functions of XPC in the protection of human skin cells from oxidative damage,” EMBO J. 25, 4305-4315, 2006.

  197. Datta, K., Jaruga, P., Dizdaroglu, M., Newmann, R. D. and Winters, T. A., “Molecular analysis of base damage clustering associated with a site-specific radiation-induced DNA double-strand break,” Radiat. Res. 166, 767-781, 2006.

  198. Nyaga, S. G., Lohani, A., Jaruga, P., Trzeciak, A., Dizdaroglu, M. and Evans, M. K., “Reduced repair of 8-hydroxyguanine in human breast cancer cell lines,” BMC Cancer 6, 297, 2006.

  199. D’Errico, M., Parlanti, E., Teson, M., Degan, P., Lemma, T., Calcagnile, A., Iavarone, I., Jaruga, P., Ropolo, M., Pedrini, A. M., Frosina, G., Zambruno, G., Dizdaroglu, M., Stefanini, M. and Dogliotti, E., “The lack of CSA leads to in vivo accumulation of oxidatively modified DNA bases in human cells,” Oncogene (in press).

  200. Rodriguez, H., Jaruga, P., Nyaga, S. G., Evans, M. K. and Dizdaroglu, M.,  “Lymphoblasts of women with BRCA1 mutations are deficient in cellular repair of 8,5' -cyclopurine-2' -deoxynucleosides and 8-hydroxy-2' -deoxyguanosine,” Biochemistry (in press).

  201. Roy, L., Jaruga, P., Wood, T. G., McCullough, A. K., Dizdaroglu, M. and Lloyd, R. S., “Human polymorphic variants of the NEIL1 DNA glycosylase: Potential implications for human health,” J. Biol. Chem. (in press).

INVITED TALKS

  1. "Radiation Chemistry of Peptides". U.S. Department of Agriculture Eastern Regional Center, Philadelphia, PA, March 1980.

  2. "Ion-Exchange HPLC of Peptides". University of Maryland, Baltimore, October 1981.

  3. "Separation of Peptides by Weak-Anion Exchange HPLC". University of Delaware, Newark, DE, November 1981.

  4. "Radiation-Induced Products of Peptides and Proteins". Massachusetts Institute of Technology, Cambridge, MA, October 1982.

  5. "Weak-Anion Exchange HPLC of Peptides". The Washington Chromatography Discussion Group, Rockville, MD, September 1982.

  6. "Enzymatic Digestibility of Peptides Crosslinked by Ionization Radiation". Middle East Technical University, Ankara, Turkey, June 1983.

  7. "The Application of GC-MS to Identification of Radiation-Induced DNA Base Damage and DNA Base-Amino Acid Crosslinks". Hewlett-Packard Company, Baltimore, MD, September 1983.

  8. "The Use of GC-MS for Characterization of Radiation-Induced DNA Base Damage". Armed Forces Radiobiology Research Institute, Bethesda, MD, April 1985.

  9. "Mechanisms of Free Radical Crosslinking in Biological Model Systems". The 33rd Annual Meeting of the Radiation Research Society, Los Angeles, CA, May 1985.

  10. "Chemical Analysis of Irradiated Foods". The Annual Meeting of the American Nuclear Society, Boston, MA, June 1985.

  11. "Mechanisms of Biological Crosslinks in Model Systems". National Research Council, Ottawa, Canada, September 1985.

  12. "Characterization of Radiation-Induced Damage in DNA". National Research Council, Ottawa, Canada, September 1985.

  13. "Oxidative Base Damage to DNA". University of Medicine, New Jersey Medical School, Newark, NJ, October 1985.

  14. "Characterization of Oxidative Base Damage to DNA". Gerontology Research Center, National Institute of Aging, Baltimore, MD, March 1986.

  15. "The use of Gas Chromatography-Mass Spectrometry for Characterization of DNA Base Damage at Low Radiation Doses". The 34th Annual Meeting of the Radiation Research Society, Las Vegas, NV, April 1986.

  16. "Radiation-Induced Damage to DNA and Its Detection at Low Radiation Doses". Health and Safety Research Division, Oak Ridge National Laboratory, Oak Ridge, TN, April 1986.

  17. "Detection of Free Radical-Induced Damage to DNA at Biologically Relevant Levels". Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD, May 1986.

  18. "Chemical Characterization of Radiation-Induced Damage to DNA". Lawrence Berkeley Laboratory, Berkeley, CA July 1986.

  19. "Radiation-Induced Formation of Cyclo-Purine Nucleosides in DNA". Lawrence Berkeley Laboratory, Berkeley, CA, July 1986

  20. "Chemical Characterization of Radiation-Induced Damage to DNA". Gray Laboratory, Mount Vernon Hospital, London, U.K., July 1986.

  21. "Radiation Damage to DNA and Its Detection of Low Radiation Doses Using Gas Chromatography-Mass Spectrometry". University of Rochester Medical Center, Rochester, N.Y., October 24, 1986.

  22. "Free Radical-Induced Damage to DNA". University of Pennsylvania School of Medicine, Philadelphia, PA, December 17, 1986.

  23. "Characterization of Free Radical-Induced Products in DNA". University of Pennsylvania School of Medicine, Philadelphia, PA, December 18, 1986.

  24. "Chemical Characterization of Free Radical-Induced Damage to DNA". Harvard Medical School, Dana Farber Cancer Institute, Boston, MA, June 25, 1987.

  25. "Mechanisms of Free Radical-Induced DNA-Protein Crosslinking in Nucleohistone in vitro". Gray Laboratory, Mount Vernon Hospital, London, U.K., July 29, 1987.

  26. "Measurement and Significance of Free Radical Damage to DNA". The Winter Meeting of The Society for Free Radical Research, London, U.K. December 14, 1987.

  27. "Chemical Characterization of Oxidative Damage to DNA". Bowman Gray School of Medicine, Winston-Salem, NC. May 3, 1988.

  28. "Oxidative Damage to DNA and Its Measurement". American University, Department of Chemistry, Washington, DC. September 29, 1988.

  29. "Measurement of DNA Base Damage and DNA-Protein Crosslinks". Symposium on Ionizing Radiation Damage to DNA: Molecular Aspects. Lake Tahoe, CA, January 19, 1990.

  30. "Measurement of free radical-induced DNA lesions in mammalian chromatin". Workshop on Non-invasive Measures of Oxidative Stress, National Cancer Institute, Bethesda, MD, February 20, 1990.

  31. "Chemistry of Free Radical Action on Mammalian Chromatin". Hillebrand Address, National Naval Medical Center, Bethesda, MD. March 8, 1990.

  32. "Oxidative DNA damage in mammalian chromatin and its measurement". Workshop on Role of Nutrition in Cancer Development. National Cancer Institute, Bethesda, MD, March 20, 1990.

  33. "Chemistry of free radical-induced damage to mammalian chromatin in vitro and in vivo". Max-Planck-Institute for Radiation Chemistry, Mülheim a.d. Ruhr, W. Germany, June 25, 1990.

  34. "DNA damage in mammalian cells caused by free radicals". Institut Gustave-Roussy, Villejuif, Paris, France, June 28, 1990.

  35. "DNA damage by oxygen-derived free radicals". Invited talk at the National Meeting of the American Chemical Society, Washington, DC, August 28, 1990.

  36. "Radiation chemistry of DNA". Georgetown University Medical Center, Washington, DC, September 13, 1990.

  37. "Free radical-induced DNA damage in mammalian chromatin in vitro and in vivo". City of Hope National Medical Center, Duarte, CA, November 19, 1990.

  38. "Mechanisms of free radical action on mammalian chromatin". National Cancer Institute, Frederick, MD, January 24, 1991.

  39. "Mechanisms of free radical-induced DNA-protein cross-linking in mammalian chromatin". National Institutes of Health, Bethesda, MD, March 1, 1991.

  40. "Measurement of DNA damage by gas chromatography-mass spectrometry". 9th International Congress of Radiation Research, Toronto, Canada, July 10, 1991.

  41. "Is there a relevance of in vitro DNA damage to in vivo DNA damage?". 9th International Congress of Radiation Research, Toronto, Canada, July 11, 1991.

  42. "Mechanisms of oxidative DNA damage in chromatin in vitro and in vivo". University of Düsseldorf, Department of Physiological Chemistry, Germany, July 15, 1991.

  43. "DNA damage in chromatin". Max-Planck-Institute for Radiation Chemistry, Mülheim a.d. Ruhr, Germany, July 17, 1991.

  44. "Free radical-induced DNA damage in chromatin in vitro and in vivo". Oxygen Club of the Greater Washington Area, National Naval Medical Center, Bethesda, MD, October 8, 1991.

  45. "Measurement of Oxidative DNA damage in mammalian chromatin by GC/MS". Hewlett-Packard Users' Meeting, Washington, DC, May 31, 1992.

  46. "DNA Base Damage and DNA-Protein Cross-links in Chromatin of g-Irradiated of H2O2-Treated Cultured Human Cells". VI Biennial Meeting of the International Society of Free Radical Research, Turin, Italy, June 20, 1992.

  47. "Free Radical-Induced DNA Damage in Mammalian Cells". Department of Clinical Biochemistry, Medical School, Bydgosczs, Poland, June 22, 1992.

  48. "Chemical Determination of Free Radical-Induced Damage to DNA". Institute of Human Genetics of the Polish Academy of Sciences, Poznan, Poland, June 24, 1992.

  49. "DNA Damage by Free Radicals". Faculty of Pharmacy, University of Ankara, Ankara, Turkey, July 24, 1992.

  50. "Radiation Chemistry". Georgetown University Medical Center, Department of Radiation Medicine, Washington, DC, September 17, 1992.

  51. "Oxidative DNA Damage in Mammalian Chromatin". Chromatography Discussion Group, Hewlett-Packard Company, Rockville, MD, November 19, 1992.

  52. "Metal Ion-Mediated Oxidative Damage DNA Damage in Mammalian Chromatin in vitro and in vivo". Second International Meeting on Molecular Mechanisms of Metal Toxicity and Carcinogenicity. Madonna di Campiglio, Italy, January 10, 1993.

  53. "DNA Damage by Oxygen-Derived Species". 27th Middle Atlantic Regional Meeting of the American Chemical Society, Hofstra University, Long Island, NY, June 3, 1993.

  54. "Oxidative DNA Damage and Its Measurement by Gas Chromatography-Mass Spectrometry". European Research Conference on Mechanisms of DNA Repair, Oxidative Damage, Oslo, Norway, June 24, 1993.

  55. "DNA Damage". Science Award Ceremony, Scientific and Technological Research Council of Turkey, Ankara, Turkey, September 6, 1993.

  56. "Radiation Chemistry of DNA". Georgetown University Medical Center, Department of Radiation Medicine, Washington, DC, September 24, 1993.

  57. "Oxidative and Radiation Damage to DNA". The Ancient DNA Conference. Smithsonian Institution, Washington, DC, October 7, 1993.

  58. "DNA Damage and Repair". Bilkent University, Ankara, Turkey, November 4, 1993.

  59. "Oxidative and Free Radical-induced DNA Damage". Meeting on Oxidative Stress and Cellular Damage, Turkish Medical Association, University of Ankara, Medical School, Ankara, Turkey, November 5, 1993.

  60. "Determination of DNA Damage and Repair". 42nd Annual Meeting of Radiation Research Society, Nashville, TN, May 3, 1994.

  61. "Radiation-induced DNA Lesions in Mammalian Cells". Department of Energy Contractors' Meeting, New Orleans, LO, June 8, 1994.

  62. "DNA Damage in Mammalian Cells". Gordon Research Conference on Radiation Chemistry, Salva Regina, RI, July 18, 1994.

  63. "Chemistry of Free Radical Damage to DNA and Nucleoprotein". First International Meeting on Pharmacy & Pharmaceutical Sciences, Istanbul, Turkey, September 5, 1994.

  64. "DNA Damage by Free Radicals". 4th International Marmara Medical Days, Marmara University Medical School, Istanbul, Turkey, September 7, 1994.

  65. "Chemistry of Oxidative DNA Damage". The Texas University Medical Branch, Sealy Center for Molecular Science, Galveston, TX, January 24, 1995.

  66. "Free Radical-Induced Lesions in DNA and Their Excision by DNA Repair Enzymes". National Institute of Aging, Gerontology Research Center, Baltimore, MD, April 5, 1995.

  67. "Free Radical-Induced Lesions in DNA, and Their Biological Consequences and Excision by DNA Repair Enzymes". 4th International Symposium on Pharmaceutical Sciences, Ankara, Turkey, June 30, 1995.

  68. "Oxidative DNA Damage and Its Enzymatic Repair". International Congress on Free Radicals in Health and Disease, Istanbul, Turkey, September 7, 1995.

  69. "Oxidative DNA Damage and Repair". National Cancer Institute, Frederick, MD, October 19, 1995.

  70. "Repair of Products of Oxidative DNA Base Damage in Human Cells". International Meeting on Oxidative Stress and Redox Regulation. Pasteur Institut, May 21-24, 1996, Paris, France, May 21, 1996.

  71. "Repair of Purine Lesions in DNA by Fpg Protein." Institut Gustave-Roussy, Villejuif Cedex, France, May 28, 1996.

  72. "Oxidative DNA Damage: Accumulation and Repair". FASEB Summer Conference "Clonal Senescence and Differentiation." Snowmass Village, Colorado, August 18, 1996.

  73. "Oxidative DNA Damage and Repair". American Health Foundation, White Plains, NW, February 28, 1997.

  74. "Oxidative DNA Damage and Its Toxicological Consequences". Second National Congress of Toxicology, Antalya, Turkey, April 3, 1997.

  75. "Oxidative DNA Damage; Its Repair and Biological Consequences". University of Pennsylvania, Medical School, Department of Radiation Oncology, Philadelphia, PA, May 1, 1997.

  76. "Oxidative DNA Damage and Repair". University of Maryland at Baltimore, Medical School, Cancer Center, Baltimore, MD, May 23, 1997.

  77. "Levels of DNA Damage from Radiation Compared to Endogenous Levels Resulting from Oxidative Processes". National Academy of Sciences, Commission on Life Sciences/Board on Radiation Effects Research, Washington, DC, July 21, 1997.

  78. "Mechanisms of Oxidative DNA Damage and Repair: Lesions and Their Measurement". NATO Advanced Study Institute of DNA Damage and Repair; Oxygen Radical Effects, Cellular Protection and Biological Consequences, Tekirova-Antalya, Turkey, October 14, 1997.

  79. "Measurement of Oxidized DNA Bases Using Gas Chromatography-Mass Spectrometry". 4th Annual Meeting of The Oxygen Society, San Fransisco, CA, November 20, 1997.

  80. "Facts About the Artifacts in the Measurement of Oxidative DNA Base Damage by GC/MS". Copenhagen Free Radical Meeting, Copenhagen, Denmark, May 29, 1998.

  81. "Oxidative DNA Damage and Repair". Medical School, University of South Alabama, Mobile, AL, July 16, 1998.

  82. "Substrate Specificities of DNA Glycosylases". IX Biennial Meeting International Society for Free Radical Research. Sao Paulo, Brazil, September 8, 1998.

  83. "Substrate Specificities of DNA Glycosylases for Products of Oxidative DNA Base Damage". NIH Aging Institute. Baltimore, MD, October, 14, 1998.

  84. "Oxidative DNA Damage". Special Meeting of the American Association for Cancer Research on Endogenous Mutations. Fort Myers, FL, November 12, 1998.

  85. "The Effect of Experimental Conditions on the Levels of Oxidatively Modified Bases in DNA as Measured by Gas Chromatography-Mass Spectrometry. How Many Modified Bases Are Involved? Prepurification or Not?" 4th CERLIB Winter Conferences, Biological Markers of Oxidative Stress. Valloire, France, March 24, 1999.

  86. "Substrate Specificities of DNA Glycosylases for Oxidative DNA Base Damage". Institut Gustav-Roussy, Villejuif, France, March 26, 1999.

  87. "Repair of Oxidative DNA Base Damage by DNA Glycosylases". Roswell Park Cancer Institute, Buffalo, NY, April 26, 1999.

  88. "Mechanisms of Oxidative DNA Damage". Department of Biochemistry, University of Gdansk, Gdansk, Poland, June 5, 1999.

  89. "Oxidative DNA Damage and Its Potential Use for Monitoring Oxidative Stress". NATO Advanced Study Institute on Human Monitoring After Environmental and Occupational Exposure to Chemical and Physical Agents, Tekirova-Antalya, Turkey, October 1, 1999.

  90. "The Application of the GC/MS Technique to the Measurement of DNA Damage and Repair". Gazi University, Department of Toxicology, Turkey, October 4, 1999.

  91. "Oxidative DNA Damage and Repair". School of Medicine, Louisiana State University Medical Center, Shreveport, LO, November 30, 1999.

  92. "Mechanisms of Oxidative DNA Damage and Its Processing by Base-Excision Repair". Department of Radiation Medicine, National Institutes of Health, Bethesda, MD, January 12, 2000.

  93. "Mechanisms of Oxidative DNA Damage and its Processing by Base-Excision Repair". Department of Cellular Biology, Colorado State University, Fort Collins, CO, February 17, 2000.

  94. "Oxidative DNA Damage; Mechanisms of Product Formation and Repair by Base-Excision Pathway". Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland, April 11, 2000.

  95. "Oxidative DNA Damage; Mechanisms of Product Formation and Repair by Base-Excision Pathway." The 10th Biennial Meeting of the International Society for Free Radical Research, Kyoto, Japan, October 17, 2000.

  96. "Base-excision repair of oxidative DNA damage: Measurement and substrate specificities." Banyu Tsukuba Research Institute in Collaboration with Merck Research Laboratories, Tsukuba, Japan, October 23, 2000.

  97. "Oxidative DNA Damage; Mechanisms of Product Formation and Repair by Base-Excision Pathway." Oxygen Club of the Greater Washington Area, National Institutes of Health, Bethesda, MD, November 21, 2000.

  98. "Measurement of Oxidative DNA Damage by Liquid Chromatography-Mass Spectrometry". National Institute of Aging, National Institutes of Health, Baltimore, MD, December 12, 2000.

  99. "Mechanisms and Measurement of Oxidative DNA Damage". Second International Meeting on Oxidative Stress and Aging, Maui, Hawaii, April 2, 2001.

  100. "Mechanisms and Measurement of Oxidative DNA Damage and Repair". Karmanos Cancer Institute, Medical School, Wayne State University, Detroit, MI, May 9, 2002.

  101. "Mechanisms of Oxidative DNA Damage and Repair". The Oxygen Club of Greater Washington, D.C. and Society of Experimental Biology & Medicine, Washington, D.C., 2002 Joint Conference entitled "Oxidative Stress: Molecular Mechanisms, Diseases and Therapeutics", National Institutes of Health, Bethesda, MD, June 3, 2002.

  102. "Substrate Specificities and Excision Kinetics of DNA Glycosylases for Repair of Oxidative Damage to DNA Bases". 32nd Annual Meeting of European Environmental Society, Warsaw, Poland, September 5, 2002.

  103. "Biomarkers of Oxidative DNA Damage used to detect Genetic Changes in Tissue Engineered Skin". BIOMED 2002, IXth International Symposium on Biochemical Science & Technology, Kemer, Antalya, Turkey, September 20, 2002

  104. "Oxidative DNA Damage and Repair." Ege University, Faculty of Sciences, Izmir, Turkey, September 25, 2002.

  105. "Measurement of Oxidative DNA Damage." Consultants Meeting, International Atomic Energy Agency, Vienna, Austria, July 7, 2003.

  106. “Substrate specificities of DNA glycosylases involved in base-excision repair of oxidative DNA damage,” Eight International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis, Pisa, Italy, October 7, 2003.

  107. “Oxidative DNA Damage and Its Repair by Base-excision Repair Pathway,” Instituto Superiore di Sanita, Rome, Italy, October 10, 2003.

  108. “Oxidative DNA Damage: Mechanisms, Measurement and Enzymic Repair,” NIH Research Festival, NIH, Bethesda, MD, October 15, 2003.

  109. “Repair of Oxidative DNA Damage by Base-excision Repair Enzymes and in Cells,” 1st US-EU DNA Repair Meeting: Endogenous Stress, National Conference Center, VA, October 17, 2003.

  110. "Oxidative DNA Damage: Mechanisms, Repair and Disease," National Cancer Institute, Division of Cancer Prevention, Cancer Biomarkers Research Group, Bethesda, MD, December 2, 2003.

  111. "Oxidative DNA Damage: Mechanisms, Repair and Biological Consequences," Tufts University, Human Nutrition Research Center, Vitamins and Carcinogenesis Laboratory, Boston, MA, December 9, 2003.

  112. "Oxidative DNA Damage: Mechanisms, Repair and Disease," Inaugural Meeting of the Chemical Society of Washington, Washington Section of the American Chemical Society, Wheaton, MD, January 15, 2004.

  113. "Measurement of Oxidative DNA Damage in Plants Treated with Ionizing Radiation and Other Mutagens," International Atomic Energy Agency, Vienna, Austria, March 3, 2004.

  114. “Oxidative DNA Damage: Mechanisms, Repair and Disease,” Johns Hopkins Medical School, Baltimore, MD, April 30, 2004.

  115. “Basic Radiation Chemistry,” Radiation Epidemiology Course, National Cancer Institute, NIH, Bethesda, MD, May 5, 2004.

  116. “Radiation Chemistry of DNA,” Radiation Epidemiology Course, National Cancer Institute, NIH, Bethesda, MD, May 5, 2004.

  117. “Oxidative DNA Damage: Mechanisms, Repair and Role in Disease,” Faculty of Medicine, Aydin University, Aydin, Turkey, May 11, 2004.

  118. “Oxidative DNA Damage: Mechanisms, Repair and Biological Consequences,” National Symposium on Molecular Diagnosis and Applications, Ege University, Izmir, Turkey, May 12, 2004.

  119. “Oxidative DNA Damage and Repair in Human Genetic Disease,” National Congress of the Turkish Biochemical Society, Trabzon, Turkey, May 15, 2004.

  120. “Oxidative DNA Damage and Repair in Human Genetic Disease,” Gülhane Military Medical Academy, Department of Biochemistry and Clinical Medicine, Ankara, Turkey, May 20, 2004.

  121. “Oxidative DNA Damage: Mechanisms, Repair and Role in Disease,” Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey, May 21, 2004.

  122. “Cellular Repair of Oxidative DNA Damage in Human Genetic Disease,” The 29th FEBS Congress, Warsaw, Poland, June 28, 2004.

  123. “Oxidative DNA Damage: Mechanisms, Repair and Role in Disease,” Faculty of Medicine, The 9th September University, Izmir, Turkey, July 16, 2004.

  124. “Oxidative DNA Damage: Mechanisms, Repair and Role in Disease,” Department of Biochemistry and Biophysics, Heart, Lung and Blood Institute, NIH, Bethesda, MD, September 3, 2004.

  125. “Cellular Repair of Oxidative DNA Damage in Human Genetic Disease,” Annual Meeting of the Society for Free Radical Research Europe, Birmingham, UK, July 10, 2005.

  126. “Measurement of in vivo Oxidative DNA Damage by Liquid Chromatography/Mass Spectrometry,” The 9th International Conference on Environmental Mutagens, and the 36th Annual Meeting of the Environmental Mutagen Society, San Fransisco, CA, September 6, 2005.

  127. “Repair of Formamidopyrimidines,” Mitochondrial DNA Transactions in Health and Disease, Chevy Chase, MD, September 27, 2005.

  128. “Measurement of Oxidative DNA Damage in Plants Treated with Ionizing Radiation and Other Mutagens,” Second Research Coordination Meeting of the International Atomic Energy Agency on Mutagenic Effects on the DNA Sequence in Plants, Seoul, Republic of Korea, November 15, 2005.

  129. “Base Excision Repair of Formamidopyrimidines,” 2nd EU-US DNA Repair Meeting, Erice, Sicily, Italy, November 29, 2005.

  130. “Oxidative DNA damage: Mechanisms, Measurement and Repair,” Trevigen, Inc., Gaithersburg, MD, February 3, 2006.

  131. “Oxidative DNA Damage and Its Repair in Cancer,” Multidisciplinal Cancer Symposium, Bursa, Turkey, March 12, 2006.

  132. “Oxidative DNA Damage: Mechanisms, Repair and Disease,” Turkish Academy of Sciences, Istanbul, Turkey, March 20, 2006.

  133. “Base Excision Repair of Formamidopyrimidines in DNA,” 2nd Baltimore Area Repair Symposium: DNA Damage and Repair in Cancer, Baltimore, MD, March 22, 2006.

  134. “Formation and Repair of Radiation-Induced Formamidopyrimidines in DNA,” IXth International Workshop on Radiation Damage to DNA, Tekirova, Antalya, Turkey, May 14, 2006.

  135. “Oxidative DNA Damage: Mechanisms, Repair and Disease,” National Institute on Aging, NIH, Baltimore, MD, October 12, 2006.

  136. “Detection of low amounts of oxidative DNA damage in living organisms using mass spectrometric techniques,” Annual Meeting of the Japanese Mutagen Society, Osaka, Japan, November 21, 2006.

  137. “Repair of oxidative DNA damage by DNA glycosylases,” Hiroshima University, Hiroshima, Japan, November 22, 2006.

  138. “Oxidative DNA damage: Mechanisms, Repair and Disease,” Kyoto University, Kyoto, Japan, November 24, 2006.