Anne L. Plant

100 Bureau Drive Stop 8313
Gaithersburg, MD 20899-8313
Phone: 301-975-3124
Email: anne.plant@nist.gov

Education

  • Ph.D.: Biochemistry, Baylor College of Medicine, Houston, TX

Current Research

  • Quantitative cell biology using fluorescence microscopy
  • Controlled surface chemistries at the micro- and nano-scale for studies of cell response to extracellular matrix proteins
  • Structure and function of biological membranes and membrane-bound proteins; Biophysics of model membranes that have potential application as sensor, medical diagnostics, and research tools.
  • Biomolecular interactions at surfaces.

 

Selected Publications:

  1. Plant, A.L. and Horowitz, E. Symposium on Metrology and Standards for Cell Signaling: Impact on Tissue Engineering. Tissue Engineering (Accepted for Publication).
  2. J.T. Elliott†*, K.J. Langenbach†, A. Tona§, P.L. Jones¶ and A.L. Plant† Vascular smooth muscle cell response on thin films of collagen. (Submitted to Matrix Biology).
  3. Elliott, J.T., Jones, P.L., Woodward, J.T., Tona, A. and Plant, A.L. (2002) Morphology of smooth muscle cells on thin films of collagen. Langmuir 19: 1506-1514.
  4. Chapados, R. McKean, D. Sisbarro, L., Elliot, J., Plant, A. and Jones, P.L Extracellular matrix-regulated expression of tenascin-C in vascular smooth muscle cells is cell shape-dependent. (Submitted to Circulation Research).
  5. John. T. Elliott, Alessandro Tona, John T. Woodward, Curtis W. Meuse, Hoda M. Elgendy, and Anne L. Plant.  (2004) Osteoblast Cell Membrane Hybrid Bilayers for Studying Cell-Cell Interactions.  IEE Procedings : Nanobiotechnology.
  6. Elliott, J.T., Tona, A., Plant,A. L.  (2002) Comparison of reagents for shape analysis of fixed cells by automated fluorescence microscopy. Cytometry 52A: 90-100.
  7. Silin,V., Wieder,H., Woodward,J.T., Valincius,G., Offenhauser,A., Plant,A.L. (2002) The role of surface free energy on the formation of hybrid bilayer membranes. J.Amer.Chem.Soc. 124: 14676-14683.
  8. Majkrzak, C. F., Berk, N. F., Krueger, S., Dura, J. A., Tarek, M., Tobias, D., Silin, V., Meuse, C. W., Woodward, J. and Plant, A. L. (2000)  First-Principles Determination of Hybrid Bilayer Membrane Structure by Phase-Sensitive Neutron Reflectometry. Biophys. J. 79: 3330-3340.
  9. Glazier, S.A., Vanderah, D.L., Plant, A.L., Bayley, H., Kasianowicz, J.J. (2000) Reconstitution of the pore-forming toxin, -hemolysin, in phospholipid/1-thiahexa(ethyleneoxide) alkane-supported bilayers. Langmuir 16: 10428-10435.
  10. Krueger, S., Meuse, C.W., Majkrzak, C.F., and Plant, A.L..  (2001) Neutron reflectivity determination of the location of melittin in hybrid bilayer membranes. Langmuir 17: 511-521.
  11. Woodward, J.T., Walker, M., Meuse, C.W., Vanderah, D., Poirier, G.E. and Plant, A.L. (2000) The effect of an oxidized gold substrate on alkanethiol self-assembly. Langmuir 16: 5347-5353.
  12. Rao, N.M., Silin, V., Woodward, J.T., Ridge, K.D., and Plant, A.L.  (2002) Cell membrane hybrid bilayers containing G-protein coupled receptors. Analytical Biochemistry  307: 117-130.
  13. Petralli-Mallow, T.P., Plant, A.L., Lewis, M.L., and Hicks, J.M. (2000) Cytochrome c at model membrane surfaces: exploration via second harmonic generation-circular dichroism and surface enhanced resonance Raman spectroscopy. Langmuir 16: 5960-5966.
  14. Petralli-Mallow, T., Briggman, K.A., Richter, L.J., Stephenson, J.C., and Plant, A.L. (1999) Nonlinear optics as a detection scheme for biomimetic sensors: SFG spectroscopy of hybrid bilayer membrane formation. SPIE 3858: 25-31.
  15. Plant, A.L. (1999) Supported hybrid bilayer membranes as rugged cell membrane mimics. Langmuir, 15:5128-5135. Invited.
  16.   Hubbard, J.B., Silin, V., Plant, A.L. (1998) Self-assembly driven by hydrophobic interactions: Mechanism of formation of lipid and cell membrane layers at alkanethiol monolayers. Biophysical Chemistry. 75:163-176.